Intensive oral care can reduce bloodstream infection with coagulase-negative staphylococci after neutrophil engraftment in allogeneic hematopoietic stem-cell transplantation
Intensive oral care can reduce bloodstream infection with coagulase-negative staphylococci after neutrophil engraftment in allogeneic hematopoietic stem-cell transplantation
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强化口腔护理可减少异基因造血干细胞移植中中性粒细胞植入后凝固酶阴性葡萄球菌的血流感染
DOI：
10.1007/s00520-021-06447-8
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发表时间：
2021
影响因子：
3.1
通讯作者：
Masuko Masayoshi
中科院分区：
文献类型：
--
作者：
Suwabe Tatsuya;Fuse Kyoko;Katsura Kouji;Soga Marie;Katagiri Takayuki;Shibasaki Yasuhiko;Narita Miwako;Sone Hirohito;Masuko Masayoshi
目的血液流感染是异基因造血干细胞移植(allo-SCT)的主要并发症。引起BSI的原因有多种，尤其是严重的口腔粘膜炎(OM)可由凝固酶阴性葡萄球菌(CONS)引起。严密的口腔护理可以减轻OM的严重程度。因此，我们评估了口腔护理类型是否最终会影响BSI的发生率。方法我们对2006-2017年间在我所接受allo-SCT的206例受者进行了回顾性分析。111例受试者由牙科专科医生实施口腔强化护理(加护组)，95例受者实施口腔自我护理(自护组)。根据口腔护理类型、中性粒细胞植入前(E-BSI前)、中性粒细胞植入后(E-BSI后)至移植后180天，对BSI的发生率进行评估。结果206例受者中，90例发生BSI，共检出细菌120株，以CONS最多见。自我护理组和重症护理组E-BSI前发生率分别为30.8%和30.6%，差异无统计学意义(P= 0.508)。重症护理组术后并发症发生率为14.3%，明显低于自我护理组的28.6%(P= 0.008)。另外，重症监护组术后并发CONS的发生率显著低于自护组(分别为8.5%和21.5%，P= 0.009)。结论通过异体血细胞移植期间的口腔护理可以显著减少E-BSI后CONS的发生，尤其是CONS。
PurposeBloodstream infection (BSI) is a major complication of allogeneic hematopoietic stem-cell transplantation (allo-SCT). There are several causes of BSI; in particular, severe oral mucositis (OM) can induce BSI due to coagulase-negative staphylococci (CoNS). The OM severity may be reduced with intensive oral care. Thus, we evaluated whether the type of oral care affects the BSI incidence eventually.MethodWe performed retrospective analysis on 206 recipients who underwent allo-SCT from 2006 to 2017 at our institute. Intensive oral care by a dental specialist was performed for 111 recipients (intensive-care group) and self-oral care was performed by 95 recipients (self-care group). Incidence of BSI was assessed by type of the oral care, before neutrophil engraftment (pre-E-BSI) and after neutrophil engraftment (post-E-BSI) period until 180 days after allo-SCT.ResultA total of 112 BSI occurred in 90 of the 206 recipients and 120 bacteria were identified, with CoNS being the most prevalent. There was no significant difference in the incidence of pre-E-BSI between the self-care and intensive-care groups (30.8% and 30.6%, respectively;P= 0.508). Meanwhile, the incidence of post-E-BSI was significantly lower in the intensive-care group than in the self-care group (14.3% and 28.6%;P= 0.008). In addition, the intensive-care group had significantly lower incidence of post-E-BSI with CoNS than the self-care group (8.5% and 21.5%, respectively;P= 0.009).ConclusionIntensive oral care through the period of allo-HCT can significantly reduce the post-E-BSI occurrence, especially due to CoNS.
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影响因子：
2.6
作者：
Almyroudis, NG;Fuller, A;Papanicolaou, GA
通讯作者：
Papanicolaou, GA
DOI：
10.1016/j.bbmt.2015.09.013
发表时间：
2016-02
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Young JH;Logan BR;Wu J;Wingard JR;Weisdorf DJ;Mudrick C;Knust K;Horowitz MM;Confer DL;Dubberke ER;Pergam SA;Marty FM;Strasfeld LM;Brown JWM;Langston AA;Schuster MG;Kaul DR;Martin SI;Anasetti C;Blood and Marrow Transplant Clinical Trials Network Trial 0201
通讯作者：
Blood and Marrow Transplant Clinical Trials Network Trial 0201
定义门诊成人造血细胞移植项目中导管相关血流感染的发生率和危险因素。
影响因子：
4.3
作者：
M. McDonald;K. Culos;Katie S. Gatwood;Caleb Prow;Heidi Chen;B. Savani;M. Byrne;A. Kassim;B. Engelhardt;M. Jagasia;G. Satyanarayana
通讯作者：
G. Satyanarayana
牙齿状况不能预测干细胞移植期间的感染：一项单中心调查
影响因子：
4.8
作者：
A. Guenther;E. Losch;M. Schiessl;A. Schrauder;A Humpe;R. Repp;T. Nitsche;J. Wiltfang;M. Gramatzki
通讯作者：
M. Gramatzki
影响因子：
4.8
作者：
Vokurka, S.;Steinerova, K.;Koza, V.
通讯作者：
Koza, V.