Phage Therapy: Future Inquiries.
Phage Therapy: Future Inquiries.
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DOI：
10.14304/surya.jpr.v1n6.3
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发表时间：
2013-06
期刊：
影响因子：
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通讯作者：
Sijia Wu;E. Zachary;Keenan Wells;C. Loc-Carrillo
中科院分区：
文献类型：
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作者：
Sijia Wu;E. Zachary;Keenan Wells;C. Loc-Carrillo
自20世纪80年代中期以来，由于抗生素耐药性问题的日益严重，西方科学家一直对噬菌体治疗产生兴趣。它在世纪由Felix d 'Herelle引入，标志着噬菌体作为抗菌剂使用的开始。然而，缺乏对噬菌体生物学的了解，以及广谱抗生素的到来，降低了西方使用噬菌体疗法治疗细菌感染的优先级。随着分子生物学的出现，我们现在能够更好地理解噬菌体与宿主共同进化的捕食者-猎物关系，以及噬菌体-宿主相互作用的特异性，这可能有助于感染的个性化治疗。这些发现使我们更深入地了解如何最有效地使用噬菌体作为潜在的治疗剂。令人鼓舞的是，噬菌体在美国被用作食品添加剂，这表明FDA承认噬菌体在人类应用中的积极潜力。不幸的是，迄今为止只有少数几个例子在对照临床试验中用于人类。严格的体外研究，尤其是体内研究，对于避免我们前人的灾难至关重要。噬菌体生物学家必须努力满足监管标准，并设计彻底的，坚固的研究，以建立一个证实需要噬菌体治疗的医疗保健。
Western scientists have steadily been gaining interest in phage therapy since the mid-1980's due to the rising problem of antibiotic resistance. Its introduction in the 20th century by Felix d'Herelle marked the beginning for the uses of bacteriophages as antibacterial agents. However, a lack in understanding phage biology, as well as the arrival of broad-spectrum antibiotics deprioritized using phage therapy to treat bacterial infections in the West. With the advent of molecular biology, we are now better able to understand the predator-prey relationships with which phage co-evolve with their hosts as well as the specificity of phage-host interactions which could lend itself into personalized treatments for infection. These discoveries give us greater insights on how to most effectively use bacteriophage as potential therapeutic agents. It is encouraging to note that bacteriophages are used as food additives in the U.S., suggesting that the FDA acknowledges the positive potential of bacteriophages for human applications. Unfortunately, there are only a few examples to date of bacteriophages used on humans in controlled clinical trials. Rigorous studies in-vitro and especially in-vivo are critically important to avoid the mishaps of our predecessors. Phage biologists must strive to meet regulatory standards and to design thorough, rugged studies in order to establish a substantiated need for phage therapy in health care.