A hybrid neural interface optrode with a polycrystalline diamond heat spreader for optogenetics
A hybrid neural interface optrode with a polycrystalline diamond heat spreader for optogenetics
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DOI：
10.1142/s2339547816400021
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发表时间：
2016-03-01
期刊：
影响因子：
--
通讯作者：
Li, Wen
中科院分区：
文献类型：
--
作者：
Fan, Bin;Kwon, Ki-Yong;Li, Wen
本文报道了一种在多晶金刚石（PCD）基底上结合发光二极管（LED）和微电极的混合光极，用于光遗传刺激和神经活动的电记录。导热PCD可以将焦耳热消散到周围区域，从而降低神经组织热损伤的风险。在重复光学刺激期间，PCD光极的最大温升小于1.3 ℃。在体内测试PCD探针的功能，其中成功检测到光诱发动作电位。
This paper reports a hybrid optrode combining light-emitting diodes (LEDs) and microelectrodes on a polycrystalline diamond (PCD) substrate, for optogenetic stimulation and electrical recording of neural activity. Thermally conductive PCD can dissipate the Joule heat to surrounding areas, and thus reduce the risk of thermal damage to nerve tissues. During repetitive optical stimulation, the maximum temperature rise of the PCD optrode was less 1.3 degrees C. The functionality of the PCD probe was tested in vivo where light-evoked action potentials were successfully detected.