Vaccine development for protecting swine against influenza virus.
Vaccine development for protecting swine against influenza virus.
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DOI：
10.1017/s1466252312000175
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发表时间：
2012-12-01
影响因子：
2.5
通讯作者：
Harris, D L Hank
中科院分区：
文献类型：
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作者：
Chen, Qi;Madson, Darin;Harris, D L Hank
流感病毒可感染多种物种，包括人、猪、马、海洋哺乳动物和鸟类。由流感感染和/或与其他感染源混合感染导致的体重减轻会给猪群带来巨大的经济损失。大流行性H1N1(A/CA/04/2009/H1N1)和H3N2V型(H3N2v)病毒的出现，对人类和牲畜构成了令人担忧的公共卫生威胁。流感病毒包含八个单链、负义RNA基因组片段。这种遗传结构使病毒能够通过抗原漂移和转变而快速进化。现有疫苗诱导的抗原特异性抗体对异源攻击的交叉保护作用有限。在猪身上，这是疫苗开发的主要障碍。目前正在开发不同的策略，以生产为猪提供更好交叉保护的疫苗。此外，压倒干扰母体抗体是流感疫苗的另一个目标，以便使小猪能够在早期有效免疫。在此，我们对猪流感病毒感染进行了综述，包括对当前疫苗途径和用于新型疫苗开发的技术进行了讨论。
Influenza virus infects a wide variety of species including humans, pigs, horses, sea mammals and birds. Weight loss caused by influenza infection and/or co-infection with other infectious agents results in significant financial loss in swine herds. The emergence of pandemic H1N1 (A/CA/04/2009/H1N1) and H3N2 variant (H3N2v) viruses, which cause disease in both humans and livestock constitutes a concerning public health threat. Influenza virus contains eight single-stranded, negative-sense RNA genome segments. This genetic structure allows the virus to evolve rapidly by antigenic drift and shift. Antigen-specific antibodies induced by current vaccines provide limited cross protection to heterologous challenge. In pigs, this presents a major obstacle for vaccine development. Different strategies are under development to produce vaccines that provide better cross-protection for swine. Moreover, overriding interfering maternal antibodies is another goal for influenza vaccines in order to permit effective immunization of piglets at an early age. Herein, we present a review of influenza virus infection in swine, including a discussion of current vaccine approaches and techniques used for novel vaccine development.