THE ROTAROD TEST - AN EVALUATION OF ITS EFFECTIVENESS IN ASSESSING MOTOR DEFICITS FOLLOWING TRAUMATIC BRAIN INJURY
THE ROTAROD TEST - AN EVALUATION OF ITS EFFECTIVENESS IN ASSESSING MOTOR DEFICITS FOLLOWING TRAUMATIC BRAIN INJURY
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DOI：
10.1089/neu.1994.11.187
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发表时间：
1994-04-01
影响因子：
4.2
通讯作者：
JENKINS, LW
中科院分区：
文献类型：
--
作者：
HAMM, RJ;PIKE, BR;JENKINS, LW
本实验的目的是检查一种改良的旋转杆试验在检测轻、中度中枢性液压脑损伤后运动功能障碍中的有效性。此外，本研究还比较了旋转棒任务与其他两种常用的脑损伤后运动功能测量（平衡梁和步行梁）的性能。将大鼠损伤为轻度（n = 14）或中度（n = 8）水平的液压冲击损伤或手术准备但未受伤（n = 8）。在其各自的处理后5天，对所有大鼠的所有任务进行评估。结果表明，轻度和中度损伤水平的动物执行转棒任务的能力产生显着的赤字。在轻度损伤水平下，平衡梁和行走梁任务的表现没有明显受损。只有在中度损伤水平，梁平衡和梁行走任务检测到运动性能的缺陷。这一结果表明，旋转棒任务是一个敏感的指标，即使是轻微的液压冲击损伤后损伤引起的运动功能障碍。功率分析的三个任务表明，统计上显着的组间差异，可以获得与旋转杆任务的样本量小得多，比梁平衡和梁行走任务。通过多变量逐步下降分析（多变量方差分析，然后是单变量协方差分析）比较和评价旋转杆、横梁行走和横梁平衡任务的表现。这项分析表明，旋转杆任务的措施方面的运动障碍，没有评估的梁平衡或梁行走潜伏期。这些结果表明，与平衡木和步行木任务相比，旋转棒任务是一个更敏感和有效的指标来评估脑损伤所产生的运动障碍。
The purpose of the present experiment was to examine the effectiveness of a modified rotarod test in detecting motor deficits following mild and moderate central fluid percussion brain injury. In addition, this investigation compared the performance of the rotarod task with two other commonly used measures of motor function after brain injury (beam-balance and beam-walking latencies). Rats were either injured with a mild (n = 14) or moderate (n = 8) level of fluid percussion injury or were surgically prepared but not injured (n = 8). All rats were assessed on all tasks for 5 days following their respective treatments. Results revealed that both the mild and moderate injury levels produced significant deficits in the ability of the animals to perform the rotarod task. Performance on the beam-balance and beam-walking tasks were not significantly impaired at the mild injury level. It was only at the moderate injury level that the beam-balance and beam-walking tasks detected deficits in motor performance. This result demonstrated that the rotarod task was a sensitive index of injury-induced motor dysfunction following even mild fluid percussion injury. A power analysis of the three tasks indicated that statistically significant group differences could be obtained with the rotarod task with much smaller sample sizes than with the beam-balance and beam-walking tasks. Performance on the rotarod, beam-walk, and beam-balance tasks were compared and evaluated by a multivariate stepdown analysis (multiple analysis of variance followed by univariate analyses of covariance). This analysis indicated that the rotarod task measures aspects of motor impairment that are not assessed by either the beam-balance or beam-walking latency. These findings suggest that compared to the beam-balance and beam-walking tasks, the rotarod task is a more sensitive and efficient index for assessing motor impairment produced by brain injury.