The Role of Long Intergenic Noncoding RNA p21 in Vascular Endothelial Cells
The Role of Long Intergenic Noncoding RNA p21 in Vascular Endothelial Cells
复制标题
长基因间非编码 RNA p21 在血管内皮细胞中的作用
DOI：
10.1089/dna.2015.2966
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发表时间：
2015-11-01
影响因子：
3.1
通讯作者：
Yang, Jian
中科院分区：
文献类型：
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作者：
He, Chao;Ding, Jia-Wang;Yang, Jian
大的基因间长非编码RNA p21(lincRNA-p21)最近被证明在生物学功能中起着重要的作用。然而，lincRNA-p21在血管内皮细胞中的生物学作用尚不清楚。在本研究中，我们通过功能获得和功能丧失研究了lincRNA-p21在血管内皮细胞中的作用，发现lincRNA-p21促进细胞凋亡和诱导细胞周期进展。此外，lincRNA-p21作为内源性海绵直接与miR-130b结合，降低miR-130b的表达。此外，miR-130b还逆转了lincRNA-p21对血管内皮细胞生长的抑制作用。综上所述，我们的数据强调了lincRNA-p21在血管内皮细胞生长中的关键作用。
Large intergenic long noncoding RNA p21 (lincRNA-p21) has recently shown to play an important role in biological functions. However, the biological role of lincRNA-p21 in vascular endothelial cells remains unclear. In the present study, we investigated the role of lincRNA-p21 in vascular endothelial cells through gain- and loss-of-function studies and found that lincRNA-p21 promoted cell apoptosis and induced cell cycle progression. Furthermore, lincRNA-p21 acted as an endogenous sponge by directly binding to miR-130b and decreased miR-130b expression. In addition, miR-130b reversed the inhibitory effect of lincRNA-p21 on the growth of vascular endothelial cells. Taken together, our data highlight the pivotal role of lincRNA-p21 in the growth of vascular endothelial cells.