Recombination among GB virus C (GBV-C) isolates in the United States
Recombination among GB virus C (GBV-C) isolates in the United States
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DOI：
10.1099/jgv.0.000477
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发表时间：
2016-07-01
影响因子：
3.8
通讯作者：
Sherman, Kenneth E.
中科院分区：
文献类型：
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作者：
Blackard, Jason T.;Ma, Gang;Sherman, Kenneth E.
GB 病毒 C (GBV-C) 是一种非致病性黄病毒，可能在调节 HIV 疾病中发挥作用。迄今为止已发现的多种 GBV-C 基因型可能对 HIV 具有差异调节作用；然而，迄今为止发布的完整 GBV-C 序列的数量非常有限。我们对美国四名 HIV/HCV 双重感染者的全长 GBV-C 基因组进行了测序。其中两个个体的基因型间重组很明显。对其他全长 GBV-C 基因组的评估将有助于创建 GBV-C 全长、具有复制能力的分子克隆，以评估 GBV-C 基因型的表型多样性，并提供有关这种正在研究的病毒的重要分子数据。
GB virus C (GBV-C) is a non-pathogenic flavivirus that may play a role in modulating HIV disease. Multiple genotypes of GBV-C that have been identified to date that may differentially regulate HIV; however, the number of complete GBV-C sequences published to date is very limited. We sequenced full-length GBV-C genomes from four individuals with HIV/HCV co-infection in the United States. Intergenotypic recombination was evident in two of these individuals. Evaluation of additional full-length GBV-C genomes would facilitate the creation of full-length, replication-competent molecular clones of GBV-C to evaluate the phenotypic diversity of GBV-C genotypes and provide important molecular data on this understudied virus.