Spatiotemporal characteristics of surround suppression in primary visual cortex and lateral geniculate nucleus of the cat.
Spatiotemporal characteristics of surround suppression in primary visual cortex and lateral geniculate nucleus of the cat.
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DOI：
10.1152/jn.00221.2012
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发表时间：
2014-08
影响因子：
2.5
通讯作者：
S. Shimegi;A. Ishikawa;H. Kida;H. Sakamoto;Sin-ichiro Hara;Hiromichi Sato
中科院分区：
文献类型：
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作者：
S. Shimegi;A. Ishikawa;H. Kida;H. Sakamoto;Sin-ichiro Hara;Hiromichi Sato
在初级视皮层（V1）中，对经典感受野（CRF）的刺激的神经元反应主要被CRF外部呈现的刺激（经典外感受野，ECRF）抑制，这种现象被称为ECRF抑制。为了阐明麻醉猫V1区ECRF抑制的神经元机制和起源，我们采用稳态闪烁正弦光栅技术研究了V1区和外侧膝状体核（LGN）ECRF抑制的空间范围和方向特异性的时间特性。在V1中，我们发现ECRF抑制的三个组成部分：（1）局部和快速，（2）全局和快速，以及（3）全局和晚期。局部和快速分量，这是从2°的边界的CRF，开始不超过10 ms后的CRF反应的发作，并表现出低特异性的方向ECRF刺激。这些时空特性与膝状体ECRF抑制的时空特性相对应，表明V1的局部和快速分量是从LGN继承的。相反，两个全局分量显示出相对于CRF边界<15 °的相当大的空间范围和高度的方向特异性，这表明它们可能起源于皮质，而不是LGN。相应地，在丘脑皮层受体层的所有神经元中观察到局部成分，而全局成分偏向于其他层。因此，我们得出结论，皮层下和皮层机制与不同的时空属性参与ECRF抑制。
In the primary visual cortex (V1), a neuronal response to stimulation of the classical receptive field (CRF) is predominantly suppressed by a stimulus presented outside the CRF (extraclassical receptive field, ECRF), a phenomenon referred to as ECRF suppression. To elucidate the neuronal mechanisms and origin of ECRF suppression in V1 of anesthetized cats, we examined the temporal properties of the spatial extent and orientation specificity of ECRF suppression in V1 and the lateral geniculate nucleus (LGN), using stationary-flashed sinusoidal grating. In V1, we found three components of ECRF suppression: (1) local and fast, (2) global and fast, and (3) global and late. The local and fast component, which resulted from within 2° of the boundary of the CRF, started no more than 10 ms after the onset of the CRF response and exhibited low specificity for the orientation of the ECRF stimulus. These spatiotemporal properties corresponded to those of geniculate ECRF suppression, suggesting that the local and fast component of V1 is inherited from the LGN. In contrast, the two global components showed rather large spatial extents ∼5° from the CRF boundary and high specificity for orientation, suggesting that their possible origin is the cortex, not the LGN. Correspondingly, the local component was observed in all neurons of the thalamocortical recipient layer, while the global component was biased toward other layers. Therefore, we conclude that both subcortical and cortical mechanisms with different spatiotemporal properties are involved in ECRF suppression.