Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature
Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature
复制标题
日本原发性鼻咽粘液表皮样癌：两例组织化学和免疫组织化学分析及文献综述
作者：
K. Kusafuka;Y. Takizawa;Y. Iida;M. Ebihara;T. Onitsuka;T. Kameya
黏液表皮样癌是一种常见的唾液腺肿瘤。涎腺型肿瘤在鼻咽部非常罕见，鼻咽部粘液表皮样癌的报道也很少。本文报告另外两例鼻咽部粘膜表皮样癌。病例1：患者为57岁日本女性，痰血。病例2：患者为51岁日本女性，接受鼻咽肿瘤切除术。组织学上，两例肿瘤均为低级别粘液表皮样癌，伴有透明细胞。组织化学上，腺样巢和黏液细胞黏素染色阳性。免疫组化结果显示，病变细胞角蛋白（ck）、p63和MUC1阳性，但α -平滑肌肌动蛋白和EBER mRNA阴性。两种肿瘤的Ki-67标记指数分别为10.4%和4.3%。这两个目前的病例和回顾的英文文献表明，唾液腺型肿瘤起源于鼻咽是非常罕见的。鼻咽部涎腺型癌的预后尚不清楚。
Mucoepidermoid carcinoma is a common neoplasm of the salivary glands. Salivary gland-type neoplasms are very rare in the nasopharynx, and there are only few reports on mucoepidermoid carcinoma of the nasopharynx. Two additional cases of mucoepidermoid carcinoma arising from the nasopharynx are reported here. Case 1: the patient was a 57-year-old Japanese woman who had bloody sputum. Case 2: the patient was a 51-year-old Japanese woman who underwent resection of a nasopharyngeal tumor. Histologically, both tumors were also low-grade mucoepidermoid carcinomas with clear cells. Histochemically, the gland-like nests and mucous cells were positive for mucin staining. Immunohistochemically, the lesions were positive for cytokeratins (CKs), p63, and MUC1, but negative for alpha-smooth muscle actin and EBER mRNA. The Ki-67 labeling indices of the two tumors were 10.4% and 4.3%, respectively. The two present cases and a review of the English literature indicate that salivary gland-type neoplasms arising from the nasopahrynx are extremely rare. The prognosis of salivary gland-type carcinomas of the nasopharynx is still unknown.
影响因子：
3.8
作者：
HU, LF;ZABAROVSKY, ER;WINBERG, G
通讯作者：
WINBERG, G