Treatment of fever after stroke: conflicting evidence.
Treatment of fever after stroke: conflicting evidence.
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DOI：
10.1592/phco.31.11.1085
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发表时间：
2011-11
期刊：
影响因子：
4.1
通讯作者：
Fagan SC
中科院分区：
文献类型：
--
作者：
Wrotek SE;Kozak WE;Hess DC;Fagan SC
大约50%的中风住院患者出现发热。事实上，实验证据表明，高体温与初始中风严重程度、病变大小、死亡率和神经学结果显著相关。卒中后发热与预后不良相关。我们调查了卒中后发热的病因，并提供证据评估用于治疗卒中相关发热的干预措施的有效性和安全性。口服退热药在降低该人群的体温升高方面仅具有轻微效果，并可能产生非预期的不良后果。非药物降温方法在达到正常体温方面更有效，但是否能改善卒中结局仍不清楚。我们建议使用体温作为生物标志物和催化剂，积极调查感染性病因。必须注意不要超过对乙酰氨基酚最大剂量3 g/天的新标准，以避免患者伤害。
Approximately 50% of patients hospitalized for stroke develop fever. In fact, experimental evidence suggests that high body temperature is significantly correlated to initial stroke severity, lesion size, mortality, and neurologic outcome. Fever occurring after stroke is associated with poor outcomes. We investigated the etiology of fever after stroke and present evidence evaluating the efficacy and safety of interventions used to treat stroke-associated fever. Oral antipyretics are only marginally effective in lowering elevated body temperature in this population and may have unintended adverse consequences. Nonpharmacologic approaches to cooling have been more effective in achieving normothermia, but whether stroke outcomes can be improved remains unclear. We recommend using body temperature as a biomarker and a catalyst for aggressive investigation for an infectious etiology. Care must be taken not to exceed the new standard of a maximum acetaminophen does of 3 g/day to avoid patient harm.
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影响因子：
48
作者：
den Hertog, Heleen M.;van der Worp, H. Bart;Dippel, Diederik W. J.
通讯作者：
Dippel, Diederik W. J.
影响因子：
8.8
作者：
Diringer, MN
通讯作者：
Diringer, MN
影响因子：
8.3
作者：
Audebert, HJ;Rott, MM;Haberl, RL
通讯作者：
Haberl, RL
影响因子：
8.3
作者：
Fagan SC;Waller JL;Nichols FT;Edwards DJ;Pettigrew LC;Clark WM;Hall CE;Switzer JA;Ergul A;Hess DC
通讯作者：
Hess DC
影响因子：
3.7
作者：
Harms H;Prass K;Meisel C;Klehmet J;Rogge W;Drenckhahn C;Göhler J;Bereswill S;Göbel U;Wernecke KD;Wolf T;Arnold G;Halle E;Volk HD;Dirnagl U;Meisel A
通讯作者：
Meisel A