The role of heme in gene expression.
The role of heme in gene expression.
复制标题
血红素在基因表达中的作用。
DOI：
10.1016/0925-5710(96)00449-5
复制
发表时间：
1996
影响因子：
2.1
通讯作者：
Nagai,T
中科院分区：
文献类型：
--
作者：
Sassa,S;Nagai,T
最近的证据表明，有显着的组织特异性表达和血红素生物合成途径中的酶的血红素介导的调节。特别地，δ-氨基乙酰丙酸合酶（ALAS）[EC 2.3. 1.37]已被证明存在组织特异性同工酶，即红细胞和非特异性ALAS，这是由两个独立的基因编码。在哺乳动物中，可以在许多组织中发现ALAS活性，在啮齿动物的哈氏腺、化学诱导的卟啉动物的肝脏和发育中的成红细胞中发现最高活性。在肝脏中，ALAS表达受血红素的负控制，而在发育中的成红细胞中，它受血红素的正影响。与这些组织相反，ALAS在哈氏腺中表达最多，并且不受血红素的影响。除了血红素生物合成的组织特异性调节外，血红素还被证明影响许多与各种组织中血红素合成不直接相关的基因功能。
Recent evidence indicates that there are significant tissue-specific expression and heme-mediated regulation of enzymes in the heme biosynthetic pathway. In particular, delta-aminolevulinate synthase (ALAS)[EC 2.3. 1.37] has been shown to exist as tissue-specific isozymes, ie the erythroid and non-specific ALAS, which are coded by two separate genes. In mammals, ALAS activity can be found in many tissues, the highest activity being found in the Harderian gland in rodents, the liver of chemically induced porphyric animals, and developing erythroblasts. In the liver, ALAS expression is under negative control by heme, while in the developing erythroblasts it is positively influenced by heme. In contrast to these tissues, ALAS is maximally expressed in the Harderian gland and is not influenced by heme. In addition to the tissue-specific regulation of heme biosynthesis, heme has also been shown to influence a number of gene functions that are not directly related to heme synthesis in various tissues.