Cellular mechanisms underlying reinforcement-related processing in the nucleus accumbens, electrophysiological studies in behaving animals
Cellular mechanisms underlying reinforcement-related processing in the nucleus accumbens, electrophysiological studies in behaving animals
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DOI：
10.1016/s0091-3057(96)00442-x
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发表时间：
1997-07-01
影响因子：
3.6
通讯作者：
Deadwyler, SA
中科院分区：
文献类型：
--
作者：
Carelli, RM;Deadwyler, SA
许多研究表明，延髓核（NA）作为一种重要的神经基质参与介导与突触相关的加工。在行为动物的电生理学研究，使直接检查细胞机制的基础上，这一过程通过表征NA活动在关键时刻，在响应食物，水，或药物奖励。电生理学研究报告，检查NA神经元的活动，在水和可卡因强化反应大鼠。这些研究表明，一些NA神经元表现出的变化（增加或减少）的放电率同步的水或可卡因的响应条件下交付。此外，NA神经元的采样人口表现出较少的同步细胞放电可卡因的反应过程中比水的奖励。可卡因自我管理过程中的NA活动明确耦合到动物的行为状态，并显着影响的刺激背景下，药物被交付。这些调查结果进行了讨论相对于NA的动态特性。活性及其作为在行为动物中介导骨水泥相关事件的潜在细胞基质的重要性。(C)1997年爱思唯尔科学公司
Numerous investigations have implicated the nucleus accumbens (NA) as an important neural substrate involved in mediating reinforcement-related processing. Electrophysiological studies in behaving animals enable a direct examination of cellular mechanisms underlying this process via characterization of NA activity at critical times during responding for food, water, or drug reward. Electrophysiological studies are reported that examined the activity of NA neurons during water- and cocaine-reinforced responding in rats. These studies reveal that some NA neurons exhibit changes (increases or decreases) in firing rate synchronized to the response-contingent delivery of water or cocaine. Furthermore, the sampled population of NA neurons exhibited less synchronized cell firing during the response for cocaine than for the water reward. NA activity during cocaine self-administration was explicitly coupled to the behavioral state of the animal and was markedly influenced by the stimulus context in which the drug was delivered. These findings are discussed with respect to the dynamic properties of NA. activity and its importance as an underlying cellular substrate mediating reinforcement-related events in the behaving animal. (C) 1997 Elsevier Science Inc.