Positive homotropic allosteric binding of benzenediols in a hydrindacene-based exoditopic receptor: Cooperativity in amide hydrogen bonding
Positive homotropic allosteric binding of benzenediols in a hydrindacene-based exoditopic receptor: Cooperativity in amide hydrogen bonding
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DOI：
10.1021/ja049336p
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发表时间：
2004-04-28
影响因子：
15
通讯作者：
Suzuki, T
中科院分区：
文献类型：
--
作者：
Kawai, H;Katoono, R;Suzuki, T
描述了基于氢化茚并省的异位受体的制备和络合性质，所述受体表现出对苯二醇的正同调变构结合过程。外向受体与间苯二酚、邻苯二酚和3-羟基苄醇形成1：2复合物，K2/K1= 3−33。熵和焓的条款是重要的，在这个变构系统的晶体学研究提供了第一个明确的证据表明，在酰胺氢键极化的协同性有助于积极的同向变构结合性能。
The preparation and complexation properties of a hydrindacene-based exoditopic receptor, that exhibits a positive homotropic allosteric binding process toward benzenediols, are described. The exoditopic receptors form 1:2 complexes with resorcinols, catechol, and 3-hydroxybenzyl alcohol withK2/K1= 3−33. Both the entropy and the enthalpy terms are important in this allosteric system; the crystallographic studies provide the first clear evidence that the cooperativity in amide hydrogen bonding by polarization contributes to the positive homotropic allosteric binding property.