Outcome of 314 patients with transient ischemic attacks.
Outcome of 314 patients with transient ischemic attacks.
复制标题
314 名短暂性脑缺血发作患者的结果。
作者：
A. Muuronen;M. Kaste
1967年至1976年，314例短暂性脑缺血发作（TIA）患者进行了评估和治疗。随访2.8 ~ 13.2年，平均7.8年。截至1979年，55名患者死于心血管疾病（28），脑血管疾病（9），恶性肿瘤（10）和其他原因（8）。在随访期间，15名患者发生脑梗死（4.8%），40名患者发生心肌梗死（12.7%）。颈动脉TIA患者与椎基底动脉TIA患者发生脑梗死的频率相同，接受抗凝治疗的患者比未接受抗凝治疗的患者更常见（p <0.05）。动脉高血压、心脏病、外周动脉疾病和糖尿病并不增加脑梗死的风险，但所有（糖尿病除外）都会增加心肌梗死的风险。TIA合并动脉高血压、热病或外周动脉疾病可增加死亡率（p <0.001）。生存1年、5年和10年的生命表分析得出男性和女性的概率分别为99%和100%、89%和91%以及60%和75%。在血压正常和高血压患者的情况下，生存1年，5年和10年的概率的生命表分析给出的概率为100%和95%。两组分别为94%和80%，76%和49%。结果明确强调动脉高血压的治疗，并证明TIA不仅是即将发生卒中的警告信号，也是心肌梗死的警告信号。
Between 1967 and 1976, 314 patients with transient ischemic attack (TIA) were evaluated and treated. Follow-up has been from 2.8 to 13.2 years (mean 7.8). As of 1979, 55 of the patients had succumbed to cardiovascular disease (28), cerebrovascular disease (9), malignancy (10), and other causes (8). During the follow-up period, 15 patients suffered brain infarction (4.8% under the risk) while 40 had myocardial infarction (12.7%) under the risk). Brain infarction occurred as often in patients with carotid TIA as in those with vertebral-basilar TIA, and was more common in patients under anticoagulation therapy than in those without it (p less than 0.05). Arterial hypertension, heart disease, peripheral arterial disease and diabetes did not increase the risk of brain infarction, but all (except diabetes) increased the risk of myocardial infarction. Combination of TIA with arterial hypertension, heat disease, or peripheral arterial disease increased the mortality (p less than 0.001). A life table analysis of surviving 1, 5, and 10 years gave probabilities of 99 and 100%, 89 and 91%, and 60 and 75% for males and females respectively. In the case of normotensive and hypertensive patients, a life table analysis of chances of surviving 1, 5, and 10 years gave probabilities of 100 and 95%. 94 and 80%, and 76 and 49% in both groups respectively. The result clearly emphasize treating of arterial hypertension, and demonstrate that TIA is not only a warning sign of impending stroke but also that of myocardial infarction.