Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis
Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis
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DOI：
10.1538/expanim.49.217
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发表时间：
2000-07-01
影响因子：
2.4
通讯作者：
Namikawa, T
中科院分区：
文献类型：
--
作者：
Anunciado, RVP;Ohno, T;Namikawa, T
在SMXA重组近交系（RI）菌株中，我们测量了每个菌株的体重、血胰岛素和脂质（甘油三酯、总胆固醇和磷脂）水平。在这5个性状中，各亚株的平均值差异显著，呈连续分布谱，表明每个性状受不同位点的多基因控制。我们还筛选了涉及这五个性状的数量性状基因座（QTL）。检测到与体重（第1和6号染色体）、胰岛素（第1、3、10和17号染色体）、甘油三酯（第4和11号染色体）和磷脂（第18号染色体）水平有关的暗示性QTL。SMXA RI品系是分析影响体重、血胰岛素和血脂水平的遗传因素的独特工具。
In the SMXA recombinant inbred (RI) strains, we measured body weight, blood insulin and lipid (triglyceride, total cholesterol and phospholipid) levels in each strain. In the five traits, mean values of substrains varied remarkably and showed a continuous spectrum of distribution, suggesting control by multiple genes at distinct loci for each trait. We also screened for quantitative trait loci (QTLs) involved in the five traits. Suggestive QTLs for body weight (Chromosomes 1 and 6), insulin (Chromosomes 1, 3, 10 and 17), triglyceride (Chromosomes 4 and 11) and phospholipid (Chromosome 18) levels were detected The SMXA RI strains are unique fools for analyzing genetic factors that influence body weight, blood insulin and lipids levels.