Regulation and function of the FGF23/klotho endocrine pathways.
Regulation and function of the FGF23/klotho endocrine pathways.
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DOI：
10.1152/physrev.00002.2011
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发表时间：
2012-01
影响因子：
33.6
通讯作者：
Quarles LD
中科院分区：
文献类型：
--
作者：
Martin A;David V;Quarles LD
钙（Ca 2+）和磷酸盐（PO 43 −）的体内平衡由全身和局部因素协调，这些因素通过复杂的激素网络调节肠道吸收、骨流入和流出以及肾脏排泄和这些离子的重吸收。传统上，甲状旁腺激素（PTH）/维生素D轴提供了理解矿物质代谢的概念框架。甲状旁腺在低钙血症时分泌的PTH通过增加肾脏对Ca 2+的重吸收和1，25-二羟维生素D [1，25（OH）2D]的产生，增强Ca 2+和PO 43 −的肠道吸收，增加Ca 2+和PO 43 −从骨的流出，同时通过磷酸盐尿效应维持中性磷酸盐平衡，从而维持血清Ca 2+水平。FGF 23是最近发现的激素，主要由成骨细胞/骨细胞产生，其主要功能是通过减少Cyp 27 b1介导的形成和刺激Cyp 24介导的1，25（OH）2D的释放来抑制肾小管磷酸盐重吸收和抑制循环1，25（OH）2D水平。FGF 23参与新的骨/肾轴，保护机体免受过量维生素D的影响，并协调肾脏PO 43 −处理与骨矿化/周转。FGF 23产生的异常是许多遗传性和获得性磷酸盐稳态障碍的基础。本文综述了FGF 23的已知和新出现的功能，其调节系统和局部信号，以及FGF 23在不同的病理和生理背景下的影响。
Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion and reabsorption of these ions through a complex hormonal network. Traditionally, the parathyroid hormone (PTH)/vitamin D axis provided the conceptual framework to understand mineral metabolism. PTH secreted by the parathyroid gland in response to hypocalcemia functions to maintain serum Ca2+ levels by increasing Ca2+ reabsorption and 1,25-dihydroxyvitamin D [1,25(OH)2D] production by the kidney, enhancing Ca2+ and PO43− intestinal absorption and increasing Ca2+ and PO43− efflux from bone, while maintaining neutral phosphate balance through phosphaturic effects. FGF23 is a recently discovered hormone, predominately produced by osteoblasts/osteocytes, whose major functions are to inhibit renal tubular phosphate reabsorption and suppress circulating 1,25(OH)2D levels by decreasing Cyp27b1-mediated formation and stimulating Cyp24-mediated catabolism of 1,25(OH)2D. FGF23 participates in a new bone/kidney axis that protects the organism from excess vitamin D and coordinates renal PO43− handling with bone mineralization/turnover. Abnormalities of FGF23 production underlie many inherited and acquired disorders of phosphate homeostasis. This review discusses the known and emerging functions of FGF23, its regulation in response to systemic and local signals, as well as the implications of FGF23 in different pathological and physiological contexts.
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影响因子：
6
作者：
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