Cancer following cardiac catheterization in childhood.
Cancer following cardiac catheterization in childhood.
复制标题
儿童时期心导管术后的癌症。
DOI：
10.1093/intjepid/29.3.424
复制
发表时间：
2000
影响因子：
7.7
通讯作者：
S. Sadetzki
中科院分区：
文献类型：
--
作者：
Baruch Modan;Lital Keinan;T. Blumstein;S. Sadetzki
背景
低剂量电离辐射是癌症发展的决定性风险因素之一。然而，只有少数后续研究的儿童进行了心导管插入术，产生不一致的结果。
方法
我们的研究组包括674名儿童谁接受了心脏导管插入术，由于先天性异常，在1950年至1970年之间，在以色列的三个主要医疗中心。一名注册护士对每家医院的儿童医疗档案进行了审查。人口数据和生命状况是通过以色列国家登记处使用一个独特的身份号码确定的。随后，研究队列与以色列国家癌症登记处联系，以确定截至1996年12月（研究的最后一次随访日期）诊断的癌症病例。
结果
超过75%的研究参与者是土生土长的; 56.2%是男性。约78%的队列受试者在随访结束时存活; 28.6%的参与者接受了一次以上的手术。所有确诊病例均为男性。所有研究中心的恶性肿瘤预期数量为4.75，而观察到的数量为11.0（标准化发病率比[SIR] = 2。3; 95% CI：1.2-4.1）。在11例癌症病例中，观察到4例淋巴瘤（预期为0.63，SIR = 6.3; 95% CI：1.7-16.2）。其中之一是霍奇金病。还有3例黑色素瘤病例，而预期为0.62例（SIR = 4.9; 95% CI：1.0-14.2）。
结论
这一发现与目前关于低剂量辐射致癌作用的知识是一致的，但在没有过量白血病的情况下发生过量淋巴瘤的情况不同，这在以前没有报道过。男性和女性之间的不和谐还有待解决。
影响
目前在心脏导管插入术中使用的辐射剂量低于过去。然而，该程序更常见，并且由于治疗干预而经常涉及更长的持续时间。应牢记这种接触可能产生的长期后果。
BACKGROUND
Low-dose ionizing radiation is one of the definitive risk factors for cancer development. Nevertheless, only a few follow-up studies of children subjected to cardiac catheterization have been performed, yielding inconsistent results.
METHODS
Our study group included 674 children who underwent cardiac catheterization due to congenital anomalies, between the years 1950-1970 in three major medical centres in Israel. A registered nurse conducted a review of the children's medical files in each hospital. Demographic data and vital status were ascertained from the Israeli National Registry, using a unique identity number. Subsequently, the study cohort was linked with the Israeli National Cancer Registry, in order to identify cancer cases that had been diagnosed through December 1996, the last follow-up date of the study.
RESULTS
Over 75% of the study participants were native-born; 56.2% were males. Approximately 78% of the cohort subjects were alive at the end of follow-up; 28.6% of the participants underwent more than one procedure. All of the diagnosed cases occurred in males. Expected number of malignancies for all sites was 4.75, while the observed number was 11.0 (standardized incidence ratio [SIR] = 2. 3; 95% CI : 1.2-4.1). Of the 11 cancer cases, 4 lymphomas were observed (0.63 were expected, SIR = 6.3; 95% CI : 1.7-16.2). One of these was Hodgkin's Disease. There were also three cases of melanoma as opposed to 0.62 expected (SIR = 4.9; 95% CI : 1.0-14.2).
CONCLUSIONS
This finding is compatible with current knowledge about the carcinogenic effect of low-dose irradiation but differs in the occurrence of an excess of lymphoma in the absence of an excess of leukaemia, which has not been reported before. The dissonance between males and females is yet to be resolved.
IMPLICATIONS
Radiation doses that are used currently during cardiac catheterization are lower than in the past. Yet, the procedure is more common and frequently involves longer duration due to therapeutic interventions. The possible long-term results of such an exposure should be kept in mind.
胸腺照射后的甲状腺肿瘤。
DOI：
--
发表时间：
1985
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Shore,RE;Woodard,E;Hildreth,N;Dvoretsky,P;Hempelmann,L;Pasternack,B
通讯作者：
Pasternack,B
非霍奇金淋巴瘤患者的 X 染色体数值异常。
影响因子：
--
作者：
Younes,A;Jendiroba,D;Katz,R;Hill,D;Cabanillas,F;Andreeff,M
通讯作者：
Andreeff,M