Kinetics of elementary Ca2+ puffs evoked in Xenopus oocytes by different Ins(1,4,5)P3 receptor agonists
Kinetics of elementary Ca2+ puffs evoked in Xenopus oocytes by different Ins(1,4,5)P3 receptor agonists
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DOI：
10.1042/bj3340505
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发表时间：
1998-09-15
影响因子：
4.1
通讯作者：
Parker, I
中科院分区：
文献类型：
--
作者：
Marchant, JS;Parker, I
基本的钙离子喷发形成了全球INS(L，4，5)P-3-诱发的钙信号的基本构件。在非洲爪哇卵母细胞中，高亲和力激动剂腺苷引起的钙泡比INS(1，4，5)P-3和低亲和力类似物INS(2，4，5)P-3引起的泡泡更短和更小。因此，激动剂特有的机制在局部钙释放事件的形成中发挥了作用，但钙离子流动的终止并不是简单地由激动剂解离来界定的。
Elementary Ca2+ puffs form the basic building blocks of global Ins(l,4,5)P-3-evoked Ca2+ signals. In Xenopus oocytes, Ca2+ puffs evoked by the high-affinity agonist adenophostin were shorter and smaller than puffs evoked by Ins(1,4,5)P-3 and the lower affinity analogue Ins(2,4,5)P-3. Agonist-specific mechanisms, therefore, play a role in shaping local Ca2+ release events, but termination of Ca2+ flux is not delimited simply by agonist dissociation.