Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV
Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV
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DOI：
10.1097/qad.0b013e32832b44c8
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发表时间：
2009-06-01
期刊：
影响因子：
3.8
通讯作者：
Costagliola, Dominique
中科院分区：
文献类型：
--
作者：
Grabar, Sophie;Selinger-Leneman, Hana;Costagliola, Dominique
目的：评估长期非进展型(LTNP)和HIV控制型患者在法国HIV1感染者队列中的患病率和特征。方法：在法国医院HIV数据库中，我们选择了2005年就诊的、感染8年以上、未接受治疗且仍无症状的患者。然后将具有这些特征的患者分类为：LTNP(=8年HIV感染和CD_4细胞最低值=500/亩L)，精英LTNP(=HIV感染8年，CD_4细胞最低值=600/亩L，且CD_4斜率为阳性)，HIV控制者(&>H IV感染10年与90%的血浆病毒载量数值
Objective: To estimate the prevalence and characteristics of long-term nonprogressor (LTNP) and HIV controller patients in a very large French cohort of HIV1-infected patients.Methods: In the French Hospital Database on HIV [FHDH, Agence Nationale de Recherches sur le SIDA et les hepatites virales (ANRS) CO4], we selected patients who had been seen in 2005, who had been infected for more than 8 years, who were treatment-naive, and who remained asymptomatic. Patients with these characteristics then categorized as follows: LTNP (>= 8 years of HIV infection and CD4 cell nadir >= 500/mu l), elite LTNP (>= 8 years of HIV infection, CD4 cell nadir >= 600/mu l, and a positive CD4 slope), HIV controllers (>10 years of HIV infection with 90% of plasma viral load values