CONSTRICTIVE ENDARTEROPATHY FOLLOWING EXPERIMENTAL SUBARACHNOID HEMORRHAGE
CONSTRICTIVE ENDARTEROPATHY FOLLOWING EXPERIMENTAL SUBARACHNOID HEMORRHAGE
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DOI：
10.1161/01.str.12.4.501
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发表时间：
1981-01-01
期刊：
影响因子：
8.3
通讯作者：
LOCKARD, J
中科院分区：
文献类型：
--
作者：
CLOWER, BR;SMITH, RR;LOCKARD, J
通过将血液注入蛛网膜下腔或机械性破裂大脑中动脉，恒河猴受到蛛网膜下腔出血的影响。对所有动物的血管进行局部脑血流、血管顺应性研究和组织学研究(光镜和EM)。在因血管破裂出血的动物中，内膜下肿胀和增厚在3天内最少出现，1个月后逐渐加重。这些变化包括严重的内膜下增殖、中膜平滑肌层纤维化和内弹力膜中断。光镜下可见内膜下增殖区的细胞具有平滑肌的超微结构特征。在蛛网膜下腔注射出血的动物中，没有证据表明动脉内膜增殖或其他血管改变，所有对照血管也是如此。与仅注射蛛网膜下腔血液或正常血管相比，暴露于机械性破裂的血管的管壁弹性降低。蛛网膜下腔出血2种方法对局部脑血流量的影响很小。
Rhesus monkeys were subjected to subarachnoid hemorrhage by either the introduction of blood into the subarachnoid space or by mechanically rupturing the middle cerebral artery. Local cerebral blood flow, vascular compliance studies and histological studies (light microscope and EM) were made of the vessels of all animals. In animals hemorrhaged via vascular rupture, subintimal swelling and thickening was minimally present by 3 days, becoming progressively more severe by 1 mo. Such changes consisted of severe subintimal proliferation, fibrosis of the medial smooth muscle layer and interruption of the internal elastic membrane. Cells in the subintimal proliferative areas examined by EM had ultrastructural characteristics of smooth muscle. In the subarachnoid-injected hemorrhaged animals, there was no evidence of intimal proliferation or other vascular changes, which was also true of all control vessels. There was a decrease in wall elasticity of vessels exposed to mechanical rupture when compared to those exposed only to injected subarachnoid blood or normal vessels. Local cerebral blood flow was affected very little following the 2 methods of subarachnoid hemorrhage.