THE BLUE-ON OPPONENT PATHWAY IN PRIMATE RETINA ORIGINATES FROM A DISTINCT BISTRATIFIED GANGLION-CELL TYPE
THE BLUE-ON OPPONENT PATHWAY IN PRIMATE RETINA ORIGINATES FROM A DISTINCT BISTRATIFIED GANGLION-CELL TYPE
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DOI：
10.1038/367731a0
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发表时间：
1994-02-24
期刊：
影响因子：
64.8
通讯作者：
LEE, BB
中科院分区：
文献类型：
--
作者：
DACEY, DM;LEE, BB
人类和旧大陆猴的色觉始于三种类型的视锥光感受器的差异激活，这三种类型的视锥光感受器对短（S）、中（M）和长（L）波长最敏感。来自三种视锥细胞类型的信号通过视锥细胞特异性双极细胞类型1 -4传递到视网膜神经节细胞。颜色编码神经节细胞分为两个主要的生理类别：红-绿对立细胞，其接收来自M-和L-敏感视锥的对抗性输入，以及蓝-黄对立细胞，其接收来自S-敏感视锥的输入，与M-和L-视锥的组合输入相反。产生颜色一致性的神经机制尚不清楚。它已被假定，这两种对手的信号被传输到外侧膝状体核的一种类型的神经节细胞，侏儒细胞5，6。我们现在报告说，一个独特的非侏儒神经节细胞类型，小bisteratified细胞，对应的生理类型，从S锥，“蓝”细胞接收兴奋性输入。因此，我们的研究结果证明了一个解剖学上不同的途径，传达S-锥信号到大脑。蓝上细胞的形态也提出了一个新的假设，视网膜电路的基础蓝黄色对手的反应。
COLOUR vision in humans and Old World monkeys begins with the differential activation of three types of cone photoreceptor which are maximally sensitive to short (S), medium (M) and long (L) wavelengths. Signals from the three cone types are relayed to the retinal ganglion cells via cone-specific bipolar cell types1-4. Colour-coding ganglion cells fall into two major physiological classes: the red-green opponent cells, which receive antagonistic input from M- and L-sensitive cones, and the blue-yellow opponent cells, which receive input from S-sensitive cones, opposed by combined M- and L-cone input. The neural mechanisms producing colour opponency are not understood. It has been assumed that both kinds of opponent signals are transmitted to the lateral geniculate nucleus by one type of ganglion cell, the midget cell5,6. We now report that a distinct non-midget ganglion cell type, the small bistratified cell, corresponds to the physiological type that receives excitatory input from S cones, the 'blue-on' cell. Our results thus demonstrate an anatomically distinct pathway that conveys S-cone signals to the brain. The morphology of the blue-on cell also suggest a novel hypothesis for the retinal circuitry underlying the blue-yellow opponent response.