RNA Degradation in Neurodegenerative Disease.
RNA Degradation in Neurodegenerative Disease.
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神经退行性疾病中的RNA降解。
DOI：
10.1007/978-3-319-89689-2_5
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发表时间：
2018
影响因子：
--
通讯作者：
Barmada SJ
中科院分区：
文献类型：
--
作者：
Weskamp K;Barmada SJ
核糖核酸（RNA）的稳态是动态调节，以响应不断变化的生理条件。通过转录和降解对RNA丰度的严格调节决定了蛋白质翻译的量、时间和位置。这种平衡在神经元中特别重要，神经元是体内代谢最活跃和形态最复杂的细胞之一。因此，RNA降解的任何中断都可能对神经元健康产生严重后果。在本章中，我们将首先讨论RNA稳定和衰变的机制。然后，我们将探讨这些通路的中断如何导致神经退行性疾病。
Ribonucleic acid (RNA) homeostasis is dynamically modulated in response to changing physiological conditions. Tight regulation of RNA abundance through both transcription and degradation determines the amount, timing, and location of protein translation. This balance is of particular importance in neurons, which are among the most metabolically active and morphologically complex cells in the body. As a result, any disruptions in RNA degradation can have dramatic consequences for neuronal health. In this chapter, we will first discuss mechanisms of RNA stabilization and decay. We will then explore how the disruption of these pathways can lead to neurodegenerative disease.