Long-Term Determinants of Muscle Strength Decline: Prospective Evidence from the 22-Year Mini-Finland Follow-Up Survey
Long-Term Determinants of Muscle Strength Decline: Prospective Evidence from the 22-Year Mini-Finland Follow-Up Survey
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DOI：
10.1111/j.1532-5415.2011.03779.x
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发表时间：
2012-01-01
影响因子：
6.3
通讯作者：
Koskinen, Seppo
中科院分区：
文献类型：
--
作者：
Stenholm, Sari;Tiainen, Kristina;Koskinen, Seppo
目的：研究握力的长期变化和预测握力下降的因素。产品设计：纵向队列研究与22年following.SETTING：人口为基础的迷你芬兰健康检查调查在Finland.PARTICIPANTS：963名男性和女性年龄在30至73 baseline.MEASUREMENTS：在基线和后续使用手持式测力计测量握力。潜在的危险因素，即生活方式和慢性疾病，以及他们在整个后续的变化是基于健康interviews.RESULTS：基于线性混合效应模型，中年体力劳动，超重，吸烟，心血管疾病，高血压，糖尿病，哮喘预测肌肉力量下降超过22年的后续（P <0.05）。此外，体重明显减轻、久坐不动、持续吸烟、冠心病、其他心血管疾病、糖尿病、慢性支气管炎、慢性背部综合征、长期心血管疾病、高血压和哮喘都与加速握力下降有关结论：生活方式和生命早期的身体健康状况决定了老年时肌肉力量下降的速度。应努力及时识别有风险的人，并针对中年人进行早期干预，以减缓肌肉力量下降，防止今后出现功能限制和残疾。J Am Geriatr Soc 60：77-85，2012.
OBJECTIVES: To examine long-term changes in handgrip strength and the factors predicting handgrip strength decline. DESIGN: Longitudinal cohort study with 22 years of follow-up.SETTING: Population-based Mini-Finland Health Examination Survey in Finland.PARTICIPANTS: Nine hundred sixty-three men and women aged 30 to 73 at baseline.MEASUREMENTS: Handgrip strength was measured using a handheld dynamometer at baseline and follow-up. Information on potential risk factors, namely lifestyle and chronic conditions, and their changes throughout the follow-up were based on health interviews.RESULTS: Based on linear mixed-effect models, midlife physically strenuous work, excess body weight, smoking, cardiovascular disease, hypertension, diabetes mellitus, and asthma predicted muscle strength decline over 22 years of follow-up (P < .05 for all). In addition, pronounced weight loss, becoming physically sedentary, persistent smoking, incident coronary heart disease, other cardiovascular disease, diabetes mellitus, chronic bronchitis, chronic back syndrome, long-lasting cardiovascular disease, hypertension, and asthma were associated with accelerated handgrip strength decline (P < .05 for all).CONCLUSION: Lifestyle and physical health earlier in life determine rate of muscle strength decline in old age. Efforts should be made to recognize persons at risk in a timely manner and target early interventions to middle-aged persons to slow down muscle strength decline and prevent future functional limitations and disability. J Am Geriatr Soc 60:77-85, 2012.