Strategic approach to the chemical synthesis of oligosaccharides
Strategic approach to the chemical synthesis of oligosaccharides
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DOI：
10.2174/157017805774296975
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发表时间：
2005-11-01
影响因子：
0.8
通讯作者：
Demchenko, AV
中科院分区：
文献类型：
--
作者：
Demchenko, AV
立体选择性糖苷合成和会聚寡糖组装的新方法和策略的发明对于糖科学领域至关重要。本说明的核心是讨论过去二十年中出现的聚合低聚糖合成策略。引言部分提供了一般的背景信息，并描述了传统的（线性）方法的寡糖合成的关键特征。随后，为了回答关键问题“我们能否更有效地合成寡糖？“等新的策略和概念，如收敛嵌段合成，武装解除，活性潜伏，正交，暂时失活和其他分类和讨论。结论部分评估了该领域的现状，并为未来的发展提供了一个视角。
The invention of new methods and strategies for stereoselective glycoside synthesis and convergent oligosaccharide assembly has been critical for the area of glycosciences. At the heart of this account is the discussion of the strategies for convergent oligosaccharide synthesis that have emerged during the past two decades. The introductory part provides general background information and describes the key features of traditional (linear) approach to oligosaccharide synthesis. Subsequently, in order to answer the key question "can we synthesize oligosaccharides more efficiently?", such novel strategies and concepts as convergent block synthesis, armed-disarmed, active-latent, orthogonal, temporary deactivation and others are categorized and discussed. The conclusions part evaluates the current standing in the field and provides a perspective for future developments.