Electroacupuncture treatment partly promotes the recovery time of postoperative ileus by activating the vagus nerve but not regulating local inflammation
Electroacupuncture treatment partly promotes the recovery time of postoperative ileus by activating the vagus nerve but not regulating local inflammation
复制标题
电针治疗通过激活迷走神经部分促进术后肠梗阻的恢复时间，但不能调节局部炎症
DOI：
10.1038/srep39801
复制
发表时间：
2017-01-04
影响因子：
4.6
通讯作者：
Liu, Zhe
中科院分区：
文献类型：
--
作者：
Fang, Jun-fan;Fang, Jian-qiao;Liu, Zhe
腹部手术后术后肠梗阻（POI）显著降低患者的生活质量，增加医院费用。然而，很少有治疗策略能够成功缩短POI的持续时间。电针是一种现代针灸方式，在世界范围内广泛应用于各种胃肠疾病。本文研究了EA对POI的影响及其潜在机制。肠道操作导致胃肠道转运、结肠转运和胃排空的明显延迟。手术也可上调孤立束核（NTS）的c-fos，并诱导小肠炎症反应。此外，手术和吸入麻醉在整个观察时间内抑制了NTS神经元的兴奋持续时间。ST36给予EA确实缩短了胃肠道和结肠运输的恢复时间，并显著增加了胃排空。EA也显著激活了术后NTS神经元。但在整个实验过程中，EA均无抗炎作用。最后，阿托品在术后注射阻断EA对胃肠道功能的调节作用，而在术前没有。由此可见，EA对POI的调节作用主要是通过刺激NTS神经元改善胃肠道转运功能，而不是通过激活胆碱能抗炎通路。
Postoperative ileus (POI) after abdominal surgery significantly lowers the life quality of patients and increase hospital costs. However, few treatment strategies have successfully shortened the duration of POI. Electroacupuncture (EA) is a modern way of administering acupuncture and widely used in various gastrointestinal (GI) diseases in the world. Here, we studied the effect of EA on POI and its underlying mechanisms. Intestinal manipulation resulted in significant delays of GI transit, colonic transit and gastric emptying. Surgery also up-regulated c-fos in nucleus of the solitary tract (NTS) and induced inflammation response in the small intestine. Further, operation and inhale anesthesia inhibited NTS neuron excitation duration for the whole observation time. EA administered at ST36 indeed shortened the recovery time of GI and colonic transit, and significantly increased the gastric emptying. EA also significantly activated the NTS neurons after operation. However, there was no anti-inflammation effect of EA during the whole experiment. Finally, atropine blocked the regulatory effect of EA on GI function, when it was injected after surgery, but not before surgery. Thus, the regulatory effect of EA on POI was mainly mediated by exciting NTS neurons to improve the GI tract transit function but not by activating cholinergic anti-inflammatory pathway.