High-Intensity Focused Ultrasound for Treatment of Symptomatic Benign Thyroid Nodules: A Prospective Study
High-Intensity Focused Ultrasound for Treatment of Symptomatic Benign Thyroid Nodules: A Prospective Study
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DOI：
10.1148/radiol.2017161640
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发表时间：
2017-09-01
期刊：
影响因子：
19.7
通讯作者：
Wong, Carlos K. H.
中科院分区：
文献类型：
--
作者：
Lang, Brian Hung-Hin;Woo, Yu-Cho;Wong, Carlos K. H.
Purpose: To evaluate first-year efficacy and changes in pressure symptoms and health-related quality of life (HRQOL) after ultrasonographically (US) guided high-intensity focused ultrasound (HIFU) ablation of symptomatic benign thyroid nodules.Materials and Methods: After ethics approval and informed consent were obtained, a prospective trial was conducted. Patients with a symptomatic benign thyroid nodule were given a choice of HIFU treatment or active surveillance. Clinical and US examinations, pressure symptom scores (visual analog scale), and HRQOL questionnaires (short form-12 survey) were evaluated at baseline and at 3, 6, and 12 months. The primary outcome was change in nodule volume after 12 months. The percentage of change in nodule volume was defined as the baseline volume minus the volume at 12 months divided by the baseline volume times 100. Ablation success was defined as a reduction in volume of greater than 50%. Nodule volume was compared by using the paired ttest. Continuous variables were compared by using the Mann-Whitney U test, and categorical variables were compared by using x(2) tests.Results: Twenty-two patients underwent HIFU and 22 underwent active surveillance. Mean age was 53.11 years (range, 28-76 years) and 55.19years (range, 41-70 years), respectively. The ratio of men to women was 2: 20 and 1: 21, respectively. The 12-month mean volume reduction 6 standard deviation in the HIFU group was significant (68.87% 6 15.27 [range, 47.35%-94.89%], P
