Pharmacokinetics of stavudine in patients with AIDS or AIDS-related complex.
Pharmacokinetics of stavudine in patients with AIDS or AIDS-related complex.
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司他夫定在艾滋病或艾滋病相关综合症患者中的药代动力学。
DOI：
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发表时间：
1992
影响因子：
6.4
通讯作者：
K. Mayer
中科院分区：
文献类型：
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作者：
M. Dudley;K. K. Graham;S. Kaul;S. Geletko;L. Dunkle;M. Browne;K. Mayer
研究了司他夫定（d4 T; 2 '，3'-二氮-3 '-脱氧胸苷）在艾滋病相关综合征或艾滋病患者中的药代动力学，这些患者参加了一项剂量范围确定的I/II期研究。22例患者在首次口服0.67、1.33、2.67或4 mg/kg体重剂量后接受了研究;其中17例患者在上述剂量每日三次给药后接受了额外的稳态药代动力学评价。司他夫定吸收迅速，在研究的四个剂量水平下，平均峰值浓度为1.2-4.2 mg/L。口服剂量的34%至41%以原型药物形式经尿液排泄。血浆消除半衰期的平均值范围为1 - 1.6 h。4 mg/kg口服剂量的绝对生物利用度超过80%。首次给药后和长期给药后测得的药代动力学参数无变化。司他夫定是一种新的双脱氧核苷类药物，与现有的核苷类药物相比，口服吸收更完全，变异更小。
The pharmacokinetics of stavudine (d4T; 2',3'-didehydro-3'-deoxythymidine) were studied in patients with AIDS-related complex or AIDS enrolled in a dose-ranging phase I/II study. Twenty-two patients were studied after the first oral dose of 0.67, 1.33, 2.67, or 4 mg/kg of body weight; 17 of them underwent an additional steady-state pharmacokinetic evaluation after thrice-daily dosing of the above doses. Stavudine absorption was rapid, with mean peak concentrations of 1.2-4.2 mg/L over the four dose levels studied. From 34% to 41% of an oral dose was excreted as unchanged drug in the urine. The mean values for plasma elimination half-life ranged from 1 to 1.6 h. The absolute bioavailability of a 4 mg/kg oral dose exceeded 80%. There was no change in pharmacokinetic parameters measured after the first dose and after chronic dosing. Stavudine is a new dideoxynucleoside with more complete and less variable oral absorption than existing nucleosides used for treatment of human immunodeficiency virus infection.
Peritz F 检验：稳健多重比较检验的基本程序，用于对组平均值之间的所有差异进行统计分析。
影响因子：
7.7
作者：
Harper,JF
通讯作者：
Harper,JF
影响因子：
56.9
作者：
LARDER, BA;DARBY, G;RICHMAN, DD
通讯作者：
RICHMAN, DD
3-脱氧胸苷-2-ene 通过非易化扩散渗透人淋巴细胞 H9 细胞。
影响因子：
3.6
作者：
August,EM;Birks,EM;Prusoff,WH
通讯作者：
Prusoff,WH