Maternal drinking behavior and decreased intrauterine growth.
Maternal drinking behavior and decreased intrauterine growth.
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母亲的饮酒行为和子宫内生长速度下降。
DOI：
10.1111/j.1530-0277.1982.tb04998.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Sokol,RJ
中科院分区：
文献类型：
--
作者：
Kuzma,JW;Sokol,RJ
在动物和人类怀孕期间母亲饮酒会导致宫内生长减慢，这是广泛观察到的一种影响，尽管对人类的研究结果并不一致。这项前瞻性研究的目的是评估作为婴儿出生体重决定因素的酒精体积、频率和饮料来源的相对重要性，同时使用多变量技术调整其他已知的决定因素。在5，093对母婴样本中，评估了44种宫内生长的潜在决定因素。研究发现，喝啤酒的频率（控制葡萄酒、白酒和其他变量）独立地导致子宫内生长的减少，如根据胎龄调整的出生体重所测量的。在研究的变量中，发现11个变量（包括吸烟和咖啡因摄入量）对方差有显著影响（R2= 32%; p < 0.001）。喝啤酒的影响最明显的是最经常喝3%的孕妇。这些结果似乎证实了以前的建议，即怀孕期间大量饮用啤酒与宫内生长减少有关，但应谨慎解释，因为有几种替代解释的发现。因此，这些结果提出了几个需要进一步研究的领域。
Reduced intrauterine growth has been a widely observed effect of maternal alcohol use during pregnancy in both animals and humans, although results in studies of humans have been inconsistent. The goal of this prospective study was to evaluate the relative importance of volume, frequency, and beverage source of alcohol as determinants of infant birthweight, while adjusting for other known determinants using multivariate techniques. In a sample of 5,093 maternal‐infant pairs, 44 potential determinants of intrauterine growth were evaluated. The frequency of beer drinking, controlled for wine drinking, liquor drinking, and other variables, was found to contribute independently to a reduction of intrauterine growth, as measured by birth‐weight adjusted for gestational age. Of the variables explored, 11, including cigarette smoking and caffeine intake, were found to contribute significantly (R2= 32%; p < 0.001) to the variance. The effect of beer drinking was most apparent in the most frequently drinking 3% of gravidas. These results appear to confirm a previous suggestion that heavy beer drinking during pregnancy is related to decreased intrauterine growth, but should be interpreted cautiously since there are several alternative explanations for the finding. Thus, these results suggest several areas for further investigation.