Hippocampal mechanisms resolve competition in memory and perception.
Hippocampal mechanisms resolve competition in memory and perception.
复制标题
海马机制解决记忆和感知的竞争。
DOI：
10.1101/2023.10.09.561548
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Aly,Mariam
中科院分区：
文献类型：
--
作者：
Favila,SerraE;Aly,Mariam
适应性行为需要选择相关的记忆和感觉，并抑制竞争的记忆和感觉。我们假设这些机制是相互关联的，例如解决记忆竞争的海马计算也塑造了感官表征的精度，以引导选择性注意。我们利用基于fMRI的模式相似性、感受野建模和眼动追踪来测试人类执行记忆依赖性视觉搜索任务时的这一假设。在海马体中，竞争记忆的分化预测了记忆引导的眼球运动的精确性。在视觉皮层中，记忆目标位置的预备编码预测搜索成功，而竞争位置的预备编码预测搜索失败，由于干扰。这些影响相互关联：较强的海马记忆分化与视觉皮层中较低的竞争激活相关，产生更精确的预备表征。这些结果证明了记忆分化在塑造感觉表征的精确性方面的作用，突出了克服记忆和感知竞争的机制之间的联系。
Behaving adaptively requires selection of relevant memories and sensations and suppression of competing ones. We hypothesized that these mechanisms are linked, such that hippocampal computations that resolve competition in memory also shape the precision of sensory representations to guide selective attention. We leveraged fMRI-based pattern similarity, receptive field modeling, and eye tracking to test this hypothesis in humans performing a memory-dependent visual search task. In the hippocampus, differentiation of competing memories predicted the precision of memory-guided eye movements. In visual cortex, preparatory coding of remembered target locations predicted search successes, whereas preparatory coding of competing locations predicted search failures due to interference. These effects were linked: stronger hippocampal memory differentiation was associated with lower competitor activation in visual cortex, yielding more precise preparatory representations. These results demonstrate a role for memory differentiation in shaping the precision of sensory representations, highlighting links between mechanisms that overcome competition in memory and perception.