Heterogeneous representations in the superior parietal lobule are common across reaches to visual and proprioceptive targets.
Heterogeneous representations in the superior parietal lobule are common across reaches to visual and proprioceptive targets.
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DOI：
10.1523/jneurosci.2921-10.2011
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发表时间：
2011-05-04
期刊：
影响因子：
--
通讯作者：
Sabes PN
中科院分区：
文献类型：
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作者：
McGuire LM;Sabes PN
感官引导运动的规划和控制需要多个感官流的整合。虽然不同感觉模态所传达的信息经常是重叠的，但在皮层处理的早期阶段，共享信息在不同的模态中以不同的方式表示。我们问这些不同的感觉信号是如何在猕猴皮层的多模态感觉运动区。虽然一个共同的模态独立的表征可能有助于下游读出，以前的研究发现，模态特定的表征在多模态皮层反映早期的空间表征，例如视觉信号有一个更眼睛为中心的表示。我们记录了神经活动从两个顶叶区参与达到规划，区域5和内侧顶内区（MIP），动物达到视觉，视觉和本体感受相结合，本体感受的目标，同时固定他们的目光在另一个位置。与其他多模态皮质区域相比，相同的空间表示用于表示区域5和MIP中的视觉和本体感受信号。然而，这些表示是异构的。虽然我们在顶叶皮层的群体反应中观察到从后到前的梯度，从更多的以眼睛为中心到更多的以手或身体为中心的表示，但我们没有观察到专注于确定给定皮层区域的“最佳匹配”参考框架的研究所建议的简单和离散的参考框架表示。总之，我们在顶叶皮层中发现了独立于模态的空间信息表征，尽管这些表征是复杂和异质的。
The planning and control of sensory-guided movements requires the integration of multiple sensory streams. Although the information conveyed by different sensory modalities is often overlapping, the shared information is represented differently across modalities during the early stages of cortical processing. We ask how these diverse sensory signals are represented in multimodal sensorimotor areas of cortex in macaque monkeys. While a common modality-independent representation might facilitate downstream readout, previous studies have found that modality-specific representations in multimodal cortex reflect earlier spatial representations, for example visual signals have a more eye-centered representation. We recorded neural activity from two parietal areas involved in reach planning, Area 5 and the medial intraparietal area (MIP), as animals reached to visual, combined visual and proprioceptive, and proprioceptive targets while fixing their gaze on another location. In contrast to other multimodal cortical areas, the same spatial representations are used to represent visual and proprioceptive signals in both Area 5 and MIP. However, these representations are heterogeneous. While we observed a posterior-to-anterior gradient in population responses in parietal cortex, from more eye-centered to more hand- or body-centered representations, we do not observe the simple and discrete reference frame representations suggested by studies that focused on identifying the “best match” reference frame for a given cortical area. In summary, we find modality-independent representations of spatial information in parietal cortex, though these representations are complex and heterogeneous.