Intraepithelial neoplasia of the vulva.
Intraepithelial neoplasia of the vulva.
复制标题
外阴上皮内瘤变。
作者：
R. Kaufman
外阴上皮内瘤变的发生率越来越高。意识到这一点，应促使临床医生仔细检查所有患者的外阴。报告强烈建议与人乳头瘤病毒感染和外阴上皮内瘤变之间的关系。这种疾病发展为浸润性癌的频率目前尚不清楚。然而，很明显，它确实发生了。疣状和基底样型外阴上皮内瘤变均与HPV感染相关，并且通常与表现出相似形态学特征的外阴浸润性鳞状细胞癌相关。这些变化更常见于吸烟的年轻女性，而不是病变似乎与HPV无关的老年非吸烟女性。局部切除和二氧化碳激光都是治疗外阴上皮内瘤变的有效方法。选择哪种方法取决于病变的位置和大小。无论采用哪种方法，保留正常外阴解剖结构和功能是至关重要的。
Intraepithelial neoplasia of the vulva is being seen with increasing frequency. Awareness of this should prompt the clinician to carefully inspect the vulva on all patients. Reports strongly suggest a relationship between infection with human papillomavirus and vulvar intraepithelial neoplasia. The frequency with which this disease progresses to invasive carcinoma is unknown at present. However, it is obvious that it does occur. Both the warty and basaloid types of vulvar intraepithelial neoplasia are associated with HPV infection and are often associated with invasive squamous cell carcinoma of the vulva demonstrating similar morphologic characteristics. These changes are seen more often in younger women who smoke than in the older nonsmoking woman whose lesions do not appear to be HPV related. Both local excision and the carbon dioxide laser are effective for treating vulvar intraepithelial neoplasia. The choice of which approach to take depends upon the location and size of the lesion or lesions. Whichever approach is utilized, preservation of the normal vulvar anatomy and function are of paramount importance.