Broadband shifts in local field potential power spectra are correlated with single-neuron spiking in humans.
Broadband shifts in local field potential power spectra are correlated with single-neuron spiking in humans.
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DOI：
10.1523/jneurosci.2041-09.2009
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发表时间：
2009-10-28
期刊：
影响因子：
--
通讯作者：
Kahana MJ
中科院分区：
文献类型：
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作者：
Manning JR;Jacobs J;Fried I;Kahana MJ
神经科学中的一个基本问题涉及单个神经元的尖峰与局部场电位（LFP）中所见的神经元集合的聚集电活动之间的关系。因为LFP反映了尖峰活动和亚阈值事件，所以这个问题不仅仅是数据聚合问题。从20例神经外科患者的记录，我们直接检查LFPs和神经元尖峰之间的关系。研究人员在广泛的大脑区域检查了2，030个神经元，发现放电率与LFP功率谱中的宽带（2 - 150 Hz）偏移呈正相关。与此相反，窄带振荡与放电率在不同的记录网站的积极和消极。宽带功率偏移是一个更可靠的预测神经元尖峰比窄带功率偏移。这些研究结果表明，宽带LFP功率提供了有价值的信息，神经元的活动超出了窄带振荡。
A fundamental question in neuroscience concerns the relation between the spiking of individual neurons and the aggregate electrical activity of neuronal ensembles as seen in local-field potentials (LFPs). Because LFPs reflect both spiking activity and subthreshold events, this question is not simply one of data aggregation. Recording from 20 neurosurgical patients, we directly examined the relation between LFPs and neuronal spiking. Examining 2,030 neurons in widespread brain regions, we found that firing rates were positively correlated with broadband (2 – 150 Hz) shifts in the LFP power spectrum. In contrast, narrowband oscillations correlated both positively and negatively with firing rates at different recording sites. Broadband power shifts were a more-reliable predictor of neuronal spiking than narrowband power shifts. These findings suggest that broadband LFP power provides valuable information concerning neuronal activity beyond that contained in narrowband oscillations.