Prognostic value of CXCR4 expression in patients with clear cell renal cell carcinoma
Prognostic value of CXCR4 expression in patients with clear cell renal cell carcinoma
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DOI：
10.14670/hh-28.1217
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发表时间：
2013-09-01
影响因子：
2
通讯作者：
Gigante, Marc
中科院分区：
文献类型：
--
作者：
Li, Guorong;Badin, Gregory;Gigante, Marc
前言：CXCR 4的表达与不同癌症的转移性播散有关。关于其预后价值的信息在透明细胞肾细胞癌（ccRCC）中非常有限。我们的目的是探讨CXCR 4在ccRCC中的预后价值。材料和方法：104例ccRCC患者进行了研究。其中男性69例，女性35例，平均年龄64.5岁（范围：34-86岁）。免疫组化法检测CXCR 4的表达。随访12 ~ 184个月，平均79.5个月。采用Kaplan-Meier对数秩检验比较术后总生存期和癌症特异性生存期。根据考克斯回归模型进行单变量和多变量分析。结果：CXCR 4在68/104（65.4%）的肿瘤组织中表达。CXCR 4表达定位于细胞核者55/68例（80.8%），胞浆或胞膜者13/68例（19.2%）。25/68例（36.8%）呈高表达。随访期间，39例患者死亡，其中26例死于癌症。Kaplan-Meier分析显示，CXCR 4的高表达与总生存期（p=0.017）和癌症特异性生存期（p=0.022）降低相关。单变量分析表明，CXCR 4的高表达是总体生存率（p=0.020）和癌症特异性生存率（p=0.027）较差的重要因素。通过多变量分析，CXCR 4的高表达似乎是总生存率（p=0.024）和癌症特异性生存率（p=0.028）的独立因素。结论：本研究表明，高CXCR 4表达与ccRCC患者的预后不良相关。
Introduction: The expression of CXCR4 is implicated in the metastatic dissemination of different cancers. The information on its prognostic value has been very limited in clear cell renal cell carcinoma (ccRCC). Our objective was to explore the prognostic value of CXCR4 in ccRCC. Materials and methods: 104 patients with a ccRCC were studied. There were 69 men and 35 women with an average age of 64.5 years old (range: 34-86 years). The CXCR4 expression was evaluated by immunohistochemistry. The follow-up varied from 12 to 184 months with a mean of 79.5 months. Kaplan-Meier with a log rank test was performed to compare overall survival and cancer-specific survival after surgery. Univariate and multivariate analyses were performed according to the Cox regression model. Results: CXCR4 expression was found in 68/104 (65.4%) of tumor samples. CXCR4 expression was located in the nucleus in 55/68 (80.8%) cases while cytoplasm or membrane location was found in 13/68 (19.2%) cases. High expression was found in 25/68 (36.8%) cases. During follow-up, 39 patients died, of which 26 died of cancer. Kaplan-Meier analysis revealed that a high expression of CXCR4 was associated with a reduced overall survival (p=0.017) and cancer-specific survival (p=0.022). Univariate analysis indicated that a high expression of CXCR4 was a significant factor for a poorer overall survival (p=0.020) and cancer-specific survival (p=0.027). By multivariate analysis, a high expression of CXCR4 appeared to be an independent factor of overall survival (p=0.024) and cancer-specific survival (p=0.028). Conclusion: This study suggested that a high CXCR4 expression was correlated with a worse outcome for ccRCC patients.