Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer.
Long non-coding RNAs: novel prognostic biomarkers for liver metastases in patients with early stage colorectal cancer.
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长非编码RNA：早期结直肠癌患者肝转移的新型预后生物标志物。
DOI：
10.18632/oncotarget.10416
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发表时间：
2016-08-02
期刊：
影响因子：
--
通讯作者：
Zhu H
中科院分区：
文献类型：
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作者：
Kong H;Wu Y;Zhu M;Zhai C;Qian J;Gao X;Wang S;Hou Y;Lu S;Zhu H
肝转移是结直肠癌(CRC)患者的主要死亡原因。为探讨长非编码RNA(Long Non-Coding RNAs，LncRNAs)对结直肠癌肝转移的预后价值，对51例IV期大肠癌和57例I/II期大肠癌标本中的15例LncRNAs进行定量逆转录聚合酶链式反应(QRT-PCR)检测。4种lncRNAs(Gas5、H19、MEG3和YIYA)在IV期大肠癌肝转移瘤和原发灶中的表达水平差异有统计学意义。此外，Gas5和YYA的高表达水平与早期结直肠癌患者未来肝转移的发生显著相关。Kaplan-Meier分析显示，Gas5和Iya的高表达与早期结直肠癌患者预后不良有关(P值分别为0.0206和0.0005)。在多变量分析中，YYA的表达被证明是结直肠癌肝转移的独立预后指标(相对危险度=10.7；p<；0.0001)。我们的研究表明，Gas5和YIYA是早期结直肠癌患者肝转移的有前景的预后生物标志物。
Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 and Yiya) were significantly different between liver metastases and primary tumors of stage IV CRC patients. Furthermore, the high expression levels of GAS5 and Yiya were significantly associated with future occurrence of liver metastases in early stage CRC patients. Kaplan-Meier analysis showed that the high expression levels of GAS5 or Yiya were correlated with poor prognosis of early stage CRC patients (p = 0.0206 and 0.0005 for GAS5 and Yiya, respectively). Yiya expression was proved to be an independent prognostic indicator of colorectal liver metastases in a multivariate analysis (relative risk = 10.7; p < 0.0001). Our study revealed that GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients.