Peroxynitrite causes apoptosis in rat thymocytes.
Peroxynitrite causes apoptosis in rat thymocytes.
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DOI：
10.1006/bbrc.1995.2578
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发表时间：
1995-10
影响因子：
3.1
通讯作者：
M. Salgo;Giuseppe L. Squadrito;William A. Pryor
中科院分区：
文献类型：
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作者：
M. Salgo;Giuseppe L. Squadrito;William A. Pryor
过氧亚硝酸盐可引起悬浮于磷酸盐缓冲液中的大鼠胸腺细胞凋亡，如DNA片段的典型梯形图所示。这一证据表明过氧亚硝酸盐的新功能，已经知道是一种强氧化剂。过氧亚硝酸盐可以使DNA产生缺口，氧化细胞巯基，并启动导致基因组降解的凋亡过程。
Peroxynitrite is demonstrated to cause apoptosis in freshly harvested rat thymocytes suspended in phosphate buffer, as shown by the typical ladder pattern of DNA fragmentation. This evidence suggests a new function for peroxynitrite, already known to be a strong oxidant. Peroxynitrite can nick DNA, oxidize cellular thiols and initiate the apoptotic process responsible for genomic degradation.