Fetal growth and maternal exposure to particulate matter during pregnancy
Fetal growth and maternal exposure to particulate matter during pregnancy
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DOI：
10.2307/3434630
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发表时间：
1999-06-01
影响因子：
10.4
通讯作者：
Srám, RJ
中科院分区：
文献类型：
--
作者：
Dejmek, J;Selevan, SG;Srám, RJ
先前的研究报告了怀孕期间环境空气中总悬浮颗粒物和二氧化硫浓度与不良妊娠结局之间的关联。我们研究了在波西米亚北部高污染地区(Teplice区)，最大10亩(PM10)和最大2.5亩(PM2.5)的颗粒物对胎儿宫内生长迟缓(IUGR)风险的可能影响。研究小组包括Teplice区两年内所有来自欧洲的独生子女足月出生。有关生育史、健康和生活方式的信息是从母亲问卷中获得的。使用连续监测数据计算每个月妊娠期间的污染物平均浓度。为每个污染物(地砖)构建了三个区间(低、中、高)。对潜在的混杂因素进行调整后，采用Logistic回归方法对妊娠每个月的PM10和PM2.5水平计算出IUGR的优势比(OR)。胎儿宫内发育迟缓与妊娠第1个月PM10水平相关的校正OR按浓度区间递增：中等1.62[95%可信区间(CI)1.07~2.46]，高2.64(CI 1.48~4.71)。PM2.5的OR值分别为1.26(CI，0.81~1.95)和2.11(CI，1.20~3.70)。未发现胎儿宫内发育迟缓风险与颗粒物的其他关联。颗粒或其他相关空气污染物对怀孕早期胎儿生长的影响是这些结果的几种可能解释之一。这种作用的时机与目前关于IUGR发病机制的假说是一致的。另一种可能的解释是季节性因素，但可能性较小。需要更多的调查来检验这些发现和其他解释。
Prior studies reported an association between ambient air concentrations of total suspended particles and SO2 during pregnancy and adverse pregnancy outcomes. We examined the possible impact of particulate matter up to 10 mu m (PM10) and up to 2.5 mu m (PM2.5) in size on intrauterine growth retardation (IUGR) risk in a highly polluted area of Northern Bohemia (Teplice District). The study group includes all singleton full-term births of European origin over a 2-year period in the Teplice District. Information on reproductive history, health, and lifestyle was obtained from maternal questionnaires. The mean concentrations of pollutants for each month of gestation were calculated using continuous monitoring data. Three intervals (low, medium, and high) were constructed for each pollutant (tertiles). Odds ratios (ORs) for IUGR for PM10 and PM2.5 levels were generated using logistic regression for each month of gestation after adjustment for potential confounding factors. Adjusted ORs for IUGR related to ambient PM10 levels in the first gestational month increased along the concentration intervals: medium 1.62 [95% confidence interval (CI), 1.07-2.46], high 2.64 (CI, 1.48-4.71). ORs for PM2.5 were 1.26 (CI, 0.81-1.95) and 2.11 (CI, 1.20-3.70), respectively. No other associations of IUGR risk with particulate matter were found. Influence of particles or other associated air pollutants on fetal growth in early gestation is one of several possible explanations of these results. Timing of this effect is compatible with a current hypothesis of IUGR pathogenesis. Seasonal factors, one of the other possible explanations, is less probable. More investigation is required to examine these findings and alternative explanations.