Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study.
Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study.
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乳腺癌亚型预测远处转移的优先部位：一项基于 SEER 的研究
DOI：
10.18632/oncotarget.15856
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发表时间：
2017-04-25
期刊：
影响因子：
--
通讯作者：
Sun S
中科院分区：
文献类型：
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作者：
Wu Q;Li J;Zhu S;Wu J;Chen C;Liu Q;Wei W;Zhang Y;Sun S
背景与目的本研究旨在探讨乳腺癌亚型与远处转移的关系。结果共识别出243，896例患者，其中对照组226，451例。骨转移8848例，脑转移1,000例，肝转移3434例，肺转移4167例。所有亚型患者均最易发生骨转移，HR+/HER 2+亚型的骨转移发生率高达5.1%。此外，与HR+/HER 2 −亚型患者相比，HR−/HER 2+亚型患者发生脑转移的概率更高（OR = 1.978）。此外，与HER 2阴性亚型相比，在HER 2阳性亚型中更频繁地观察到肝转移。TN患者主要表现为肺转移，但各亚型的肺转移概率无差异。材料与方法使用2010-2013年监测、流行病学和最终结果计划（SEER）数据，一项回顾性、基于人群的队列研究，以调查肿瘤亚型特异性在远处转移部位的差异。提供了骨、脑、肝和肺的转移模式信息。乳腺癌分为四种亚型：激素受体（HR）+/人表皮生长因子受体2（HER 2）-，HR+/HER 2+，HR-/HER 2+和三阴性（TN）。结论不同病理亚型乳腺癌的远处转移行为存在明显差异，提示对远处转移的认识有助于制定相应的随访策略，指导个体化治疗。
Background and Aims This study aimed to access possible relationships between breast cancer subtypes and sites of distant metastasis in breast cancer. Results A total of 243,896 patients, including 226,451 cases in control groups were identified. Bone metastasis was found in 8848 cases, compared with 1,000 brain metastasis cases, 3434 liver metastasis cases and 4167 lung metastasis cases. Patients with all subtypes were most prone to bone metastases, the incidence of bone metastasis in HR+/HER2+ subtype was up to 5.1 %. Further, HR−/HER2+ subtype patients had a higher probability of brain (OR = 1.978) metastasis compared to HR+/HER2− subtype patients. In addition, liver metastasis was more frequently observed in the HER2 positive subtypes compared with HER2 negative subtypes. Patients with TN primarily presented lung metastasis, but it made no difference in the probability of lung metastases of all subtypes. Materials and Methods Using the 2010–2013 Surveillance, Epidemiology, and End Results Program(SEER) data, a retrospective, population-based cohort study to investigate tumor subtypes-specific differences in the sites of distant metastasis. Metastatic patterns information was provided for bone, brain, liver and lung. The breast cancer was classified into four subtypes: hormone receptor (HR) +/ human epidermal growth factor receptor 2 (HER2) −, HR+/HER2+, HR−/HER2+ and triple negative (TN). Conclusions The pathological subtypes of breast cancer are clearly different in metastatic behavior with regard to the sites of distant metastasis, emphasizing that this knowledge may help to determine the appropriate strategy for follow-up and guide personalized medicine.