Facing up the ROS labyrinth--Where to go?
Facing up the ROS labyrinth--Where to go?
复制标题
直面ROS迷宫——何去何从？
作者：
A. Rojas;H. Figueroa;M. Morales;L. Re
有证据表明，氧化应激是指细胞受到过量活性氧（ROS）的条件。总体血管功能取决于氧化剂和抗氧化剂机制之间的精细平衡，这至少部分地是内皮正常功能所需的。大量的实验和临床数据表明，细胞内氧化环境也参与了几种氧化还原敏感的细胞信号传导途径，如离子转运系统，蛋白磷酸化和基因表达，因此也起着重要的作用，作为血管细胞功能的调节剂，如细胞生长，凋亡，迁移，血管生成和细胞粘附。在病理生理条件下ROS的过度产生是血管疾病发展中不可或缺的一部分。这一事实刺激了对改善血管止血的新药理学方法的深入研究，特别是那些旨在降低氧化应激或增强抗氧化防御机制的方法。
Evidence indicates that oxidative stress refers to a condition where cells are subjected to excessive levels of reactive oxygen species (ROS). Overall vascular function is dependent upon a fine balance between oxidant and antioxidant mechanisms which is required, at least in part, for proper functioning of the endothelium. Considerable experimental and clinical data indicate that the intracellular oxidant milieu is also involved in several redox-sensitive cellular signaling pathways, such as ion transport systems, protein phosphorylation, and gene expression and thus also plays important roles as modulator of vascular cell function, such as cell growth, apoptosis, migration, angiogenesis and cell adhesion. Overproduction of ROS under pathophysiologic conditions is integral in the development of vascular disease. This fact stimulated an intensive search of new pharmacological approaches to improve vascular hemeostasis and, particularly those intended to decrease oxidative stress or augment the antioxidant defense mechanisms.