Laryngeal Adenocarcinoma Not Otherwise Specified: A Population-Based Perspective
Laryngeal Adenocarcinoma Not Otherwise Specified: A Population-Based Perspective
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DOI：
10.1002/lary.26055
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发表时间：
2017-02-01
期刊：
影响因子：
2.6
通讯作者：
Eloy, Jean Anderson
中科院分区：
文献类型：
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作者：
Spinazzi, Eleonora F. i;Abboud, Mohammad T.;Eloy, Jean Anderson
目的/假设：喉腺癌（LAdC NOS）是一种不符合其他特征明确的组织学亚型的喉部小唾液腺肿瘤变体。其罕见的性质和现有报告的不一致性阻碍了对这种恶性肿瘤的调查和进一步了解。在这项研究中，我们使用了一个基于国家人口的资源来评估这种罕见疾病的流行病学和生存率。研究设计：基于人群的回顾性分析。方法：检索1973 - 2012年间诊断为LAdC NOS的监测、流行病学和最终结果数据库。收集并分析患者人口统计学、肿瘤位置、TNM分期、分级、发病率和生存趋势。结果：符合LAdC NOS诊断标准的患者111例，以男性（80.2%）为主，白人（84.7%），平均年龄65岁。声门上是最常见的发病部位（38.7%）。大多数为II级肿瘤（45.7%）。TNM分期显示T2（36.8%）、N0（72.2%）和M0（88.9%）是最常见的分期。2000年至2012年的总发病率为0.008/ 10万人。总的5年疾病特异性生存率（DSS）为60.1%，而手术和放疗联合治疗的患者为85.7%。结论：LAdC NOS是一种罕见的恶性肿瘤。它最常见于60多岁的男性，不分种族。病变最常见于声门上炎，组织学级别较低。DSS在手术和放疗联合治疗的患者中最高。
Objectives/Hypothesis: Laryngeal adenocarcinoma not otherwise specified (LAdC NOS) is a category to which variants of minor salivary gland tumors of the larynx that do not fit other well-characterized histological subtypes are assigned. Its rare nature and inconsistency in available reports has hindered the investigation and further understanding of this malignancy. In this study, a national population-based resource was used to evaluate the epidemiology and survival of this rare entity.Study Design: Retrospective population-based analysis.Methods: The Surveillance, Epidemiology, and End Results database was searched for patients diagnosed with LAdC NOS between 1973 and 2012. Patient demographics, tumor location, TNM stage, grade, incidence, and survival trends were collected and analyzed.Results: One hundred eleven patients met criteria for diagnosis of LAdC NOS, of which the majority were male (80.2%), white (84.7%), with a mean age of 65 years. The supraglottis was the most common site at presentation (38.7%). The majority presented with grade II tumor (45.7%). TNM staging revealed T2 (36.8%), N0 (72.2%), and M0 (88.9%) to be the most common classification. The overall incidence between the years of 2000 and 2012 was 0.008/ 100,000 individuals. The overall 5-year disease-specific survival (DSS) was 60.1%, compared to 85.7% in patients treated with combination surgery and radiotherapy.Conclusions: LAdC NOS is an uncommon malignancy. It most commonly affects men in their mid-60s, indiscriminate of race. Lesions most commonly present in the supraglottis and are more often low grade histologically. DSS is highest in patient treated with combination surgery and radiotherapy.