Significant Decrease in the Incidence of Genital Warts in Young Danish Women After Implementation of a National Human Papillomavirus Vaccination Program
Significant Decrease in the Incidence of Genital Warts in Young Danish Women After Implementation of a National Human Papillomavirus Vaccination Program
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DOI：
10.1097/olq.0b013e31827bd66b
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发表时间：
2013-02-01
影响因子：
3.1
通讯作者：
Kjaer, Susanne K.
中科院分区：
文献类型：
--
作者：
Baandrup, Louise;Blomberg, Maria;Kjaer, Susanne K.
背景：约90%的生殖器疣(GWS)是由人类乳头瘤病毒(HPV)6型和11型引起的。丹麦自2009年以来向所有12岁女孩提供四价HPV疫苗，自2008年以来向女孩提供最长15年的补种疫苗，疫苗覆盖率高达80%至85%。我们统计了丹麦自1996年以来GWS的发病率，重点是HPV疫苗接种许可后的一段时间(2006年10月)。方法：从丹麦国家患者名册中，我们确定了1995年1月至2011年7月期间GWS的所有住院和门诊咨询情况。结果：2007年以前，女性GWS的总发病率显著增加，之后年均下降3.1%(95%可信区间[CI]，-5.5~-0.7)。在男性中，发病率自2004年以来每年增加6.2%(95%可信区间，4.6-7.8)。按年龄分层，仅在16至17岁的年轻女性中出现显著下降，在这些女性中，GW几乎被消除(年均百分比变化，-45.3%；95%CI，-55.8至-33.3)。生殖器衣原体、梅毒和淋病的发病率在研究期间保持稳定或上升。结论：在HPV疫苗接种率较高的妇女中，GWS的发病率大幅下降，这表明国家HPV疫苗接种计划的效果。
Background: Approximately 90% of genital warts (GWs) are caused by human papillomavirus (HPV) types 6 and 11. Denmark has provided the quadrivalent HPV vaccine to all 12-year-old girls since 2009 and catch-up vaccination to girls up to 15 years since 2008, with up to 80% to 85% vaccine coverage. We determined the incidence of GWs in Denmark since 1996, focusing on the period after licensing of HPV vaccination (October 2006).Methods: From the Danish National Patient Register, we identified all hospitalizations and outpatient consultations for GWs between January 1995 and July 2011. Poisson regression was used to estimate average annual percentage changes.Results: The overall incidence of GWs in women increased significantly until 2007, followed by an average yearly decline of 3.1% (95% confidence interval [CI], -5.5 to -0.7). In men, the incidence increased by 6.2% per year from 2004 (95% CI, 4.6-7.8). Stratifying on age, a significant decline was seen only for young women, particularly those aged 16 to 17 years, in whom GWs were virtually eliminated (average annual percentage change, -45.3%; 95% CI, -55.8 to -33.3). The incidences of genital Chlamydia, syphilis, and gonorrhea were stable or increased during the study period.Conclusions: The incidence of GWs decreased substantially among women with high HPV vaccine coverage, pointing to the effect of the national HPV vaccination program.