Microbiota in Pediatric Inflammatory Bowel Disease
Microbiota in Pediatric Inflammatory Bowel Disease
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DOI：
10.1016/j.jpeds.2010.02.046
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发表时间：
2010-08-01
影响因子：
5.1
通讯作者：
Koehler, Henrik
中科院分区：
文献类型：
--
作者：
Schwiertz, Andreas;Jacobi, Manuela;Koehler, Henrik
目的探讨炎症性肠病（IBD）患儿肠道菌群与疾病活动性的关系，为IBD患儿肠道菌群与疾病活动性的关系提供理论依据。根据小儿溃疡性结肠炎活动指数或小儿克罗恩病活动指数确定疾病活动。结果溃疡性结肠炎患儿肠道菌群中普氏粪杆菌和双歧杆菌的数量与正常对照组相比无明显变化，但活动期IBD患儿肠道菌群中普氏粪杆菌和双歧杆菌的数量明显减少，而活动期和非活动期克罗恩病患儿肠道菌群中普氏粪杆菌和双歧杆菌的数量明显减少结论CD患儿肠道菌群中普氏杆菌数量减少，大肠杆菌数量增加。（J Pediatr 2010; 157：240-4）。
Objective To test the hypothesis that compared with controls, children with inflammatory bowel disease (IBD) exhibit differences in the relationships between gut microbiota and disease activity.Study design Children and adolescents (n = 69; median age, 14 years) with IBD and 25 healthy controls (median age, 14 years) were recruited for the study. The disease activity was determined according to the Pediatric Ulcerative Colitis Activity Index or the Pediatric Crohn Disease Activity Index. Cell counts of 9 bacterial groups and species in the fecal microbiota were monitored by real-time polymerase chain reaction analysis.Results Although no major changes were observed in patients with ulcerative colitis, except for a decrease in bifidobacteria in the active state of IBD, children with active and inactive Crohn's disease (CD) had lower numbers of Faecalibacterium prausnitzii and bifidobacteria (P < .05), and patients with active CD had higher numbers of Escherichia coli (P < .05).Conclusions The microbiota in children with CD is characterized by decreased numbers of F praunsitzii and increased numbers of E coli. (J Pediatr 2010; 157: 240-4).