A Comparative Study of Odor Identification and Odor Discrimination Deficits in Parkinson's Disease
A Comparative Study of Odor Identification and Odor Discrimination Deficits in Parkinson's Disease
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DOI：
10.1002/mds.22155
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发表时间：
2008-10-30
影响因子：
8.6
通讯作者：
Berendse, Henk W.
中科院分区：
文献类型：
--
作者：
Boesveldt, Sanne;Verbaan, Dagmar;Berendse, Henk W.
本研究的目的是比较气味歧视和气味识别缺陷的特点，在一个大的帕金森氏病（PD）患者群体，并确定这些嗅觉测试最好区分患者与PD和对照组。在404名PD患者和150名对照者中评估了嗅觉性能。使用嗅棒电池的气味识别和辨别部件。患者的平均识别和辨别评分，，; PD组显著低于对照组。使用95%置信区间的线性回归分析显示，相对于对照组的表现，65.0%的PD患者的气味识别受损，而42.1%的患者的气味辨别任务受损。ROC曲线显示，更高的灵敏度和特异性气味识别比气味的歧视，从控制中分离患者。PD患者。气味辨别能力随着疾病持续时间的增加而降低。而气味识别与疾病阶段或持续时间无关。在PD中，气味识别比气味辨别更频繁地受损，并且允许患者和对照之间更好的辨别。虽然在气味识别缺陷通常被认为是独立的疾病进展，在气味辨别的损害似乎随着疾病的持续时间增加。(C)2008运动障碍协会
The aim of this study was to compare the characteristics of odor discrimination and odor identification deficits in a large population of patients with Parkinson's disease (PD) and to determine which of these olfactory tests best distinguishes between patients with PD and control subjects. Olfactory performance was assessed in 404 patients with PD and 150 controls. using the odor identification and discrimination parts of the Sniffin Sticks battery. Mean identification and discrimination scores in patient.,; with PD were significantly lower than in controls. Linear regression analysis using a 95% confidence interval revealed that, relative to the performance of controls, 65.0% of patients with PD had an impairment in odor identification, whereas 42.1% of patients were impaired on the odor discrimination task. ROC Curves revealed a higher sensitivity and specificity for odor identification than for odor discrimination in separating patients from controls. In patients with PD. odor discrimination performance decreased with increasing disease duration. whereas odor identification was not correlated with disease stage or duration. In PD, odor identification is more frequently impaired than odor discrimination and allows a better discrimination between patients and controls. Although in odor identification deficit is generally believed to be independent of disease progression, the impairment in odor discrimination appears to increase with disease duration. (C) 2008 Movement Disorder Society