Dopamine lesions alter the striatal encoding of single-limb gait.
Dopamine lesions alter the striatal encoding of single-limb gait.
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多巴胺损伤改变单肢步态的纹状体编码。
DOI：
10.1101/2023.10.06.561216
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Masmanidis,SotirisC
中科院分区：
文献类型：
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作者：
Yang,Long;Singla,Deepak;Wu,AlexanderK;Cross,KatyA;Masmanidis,SotirisC
纹状体在运动控制中起着重要作用，该区域的神经元编码身体运动的启动、停止和速度。然而，目前还不清楚是否同样的神经元也编码一步一步的节奏运动模式的个别肢体的特征步态。通过结合高速视频跟踪，电生理学和光遗传学标记，我们发现相当大的D1和D2受体表达的中型多刺投射神经元（MSN）群体与小鼠个体肢体的步态周期相锁定。健康动物在D1和D2 MSN之间表现出平衡的肢体锁相，而多巴胺耗尽导致D2 MSN中更强的锁相。这些研究结果表明，纹状体神经元代表步态的单肢和步骤的基础上，并建议，提高肢体锁相D2 MSNs可能是一些步态障碍与多巴胺的损失。
The striatum serves an important role in motor control, and neurons in this area encode the body’s initiation, cessation, and speed of locomotion. However, it remains unclear whether the same neurons also encode the step-by-step rhythmic motor patterns of individual limbs that characterize gait. By combining high-speed video tracking, electrophysiology, and optogenetic tagging, we found that a sizable population of both D1 and D2 receptor expressing medium spiny projection neurons (MSNs) were phase-locked to the gait cycle of individual limbs in mice. Healthy animals showed balanced limb phase-locking between D1 and D2 MSNs, while dopamine depletion led to stronger phase-locking in D2 MSNs. These findings indicate that striatal neurons represent gait on a single-limb and step basis, and suggest that elevated limb phase-locking of D2 MSNs may underlie some of the gait impairments associated with dopamine loss.