EARLY AND LATE PERIODIC PATTERNS OF EVEN SKIPPED EXPRESSION ARE CONTROLLED BY DISTINCT REGULATORY ELEMENTS THAT RESPOND TO DIFFERENT SPATIAL CUES
EARLY AND LATE PERIODIC PATTERNS OF EVEN SKIPPED EXPRESSION ARE CONTROLLED BY DISTINCT REGULATORY ELEMENTS THAT RESPOND TO DIFFERENT SPATIAL CUES
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DOI：
10.1016/0092-8674(89)90916-1
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发表时间：
1989-05-05
期刊：
影响因子：
64.5
通讯作者：
MANIATIS, T
中科院分区：
文献类型：
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作者：
GOTO, T;MACDONALD, P;MANIATIS, T
我们已经确定了果蝇配对规则基因的周期性表达所需的调控序列，甚至跳过（前夕）。我们发现，在早期胚胎发育过程中，周期性eve表达的逐渐变化的模式是由两个不同的调节程序。最初，单个条纹中的Eve表达是由不同的调控元件建立的，每个调控元件响应于至少部分由差距基因提供的非周期性空间线索。后来，eve在所有七条条纹中的协调表达是由一个单一的调节区域控制的，该区域对初级配对规则基因（包括eve本身）提供的周期性线索做出反应。由于这种两步调控程序，eve在建立基因表达的周期性模式和随后的parasegmental边界规范中发挥作用。
We have identified the regulatory sequences required for the periodic expression of the Drosophila pair rule gene even skipped (eve). We find that the gradually changing pattern of periodic eve expression during early embryogenesis is directed by two distinct regulatory programs. Initially, eve expression in individual stripes is established by different regulatory elements, each of which responds to nonperiodic spatial cues provided, at least in part, by the gap genes. Later, coordinate expression of eve in all seven stripes is directed by a single regulatory region that responds to periodic cues provided by primary pair rule genes, including eve itself. As a consequence of this two-step regulatory program, eve functions both in the establishment of the periodic pattern of gene expression and in the subsequent specification of parasegmental boundaries.