Early arterial differentiation and patterning in the avian embryo model.
Early arterial differentiation and patterning in the avian embryo model.
复制标题
禽胚胎模型中的早期动脉分化和模式。
DOI：
10.1016/j.semcdb.2011.09.019
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发表时间：
2011
影响因子：
7.3
通讯作者：
Mikawa,Takashi
中科院分区：
文献类型：
--
作者：
Garriock,RobertJ;Mikawa,Takashi
在研究血管生物学的众多模型中，禽类胚胎仍然是一个信息丰富、功能强大的模型系统，它为循环系统发育过程中内皮细胞的募集、组装和重塑提供了重要的见解。这篇综述强调了在鸟类系统中的几个发现，这些发现显示了在原肠胚形成和神经发育期间，动脉模式是如何通过沿胚胎中线发育的背主动脉模型来调节的。这些发现是通过空间和时间控制的功能获得实验得以实现的，这些实验提供了直接证据，证明BMP信号在血管募集、模式形成和重塑中起关键作用，notch信号将血管前体细胞募集到背主动脉。重要的是，BMP配体在整个胚胎中广泛表达，但BMP信号激活区域是通过BMP拮抗剂的精确调控表达而在空间上定义的。这些发现提供了对信号传导（包括正信号和负信号）如何调节血管模式的深入了解。这篇综述也说明了羊膜动物（包括鸟类和哺乳动物，包括人类）沿着胚胎中线的早期动脉模式的相似性，从非羊膜动物（如鱼和青蛙）进化而来。
Of the many models to study vascular biology the avian embryo remains an informative and powerful model system that has provided important insights into endothelial cell recruitment, assembly and remodeling during development of the circulatory system. This review highlights several discoveries in the avian system that show how arterial patterning is regulated using the model of dorsal aortae development along the embryo midline during gastrulation and neurulation. These discoveries were made possible through spatially and temporally controlled gain-of-function experiments that provided direct evidence that BMP signaling plays a pivotal role in vascular recruitment, patterning and remodeling and that Notch-signaling recruits vascular precursor cells to the dorsal aortae. Importantly, BMP ligands are broadly expressed throughout embryos but BMP signaling activation region is spatially defined by precisely regulated expression of BMP antagonists. These discoveries provide insight into how signaling, both positive and negative, regulate vascular patterning. This review also illustrates similarities of early arterial patterning along the embryonic midline in amniotes both avian and mammalians including human, evolutionarily specialized from non-amniotes such as fish and frog.