Sphingosine-1-phosphate signaling and its role in disease.
Sphingosine-1-phosphate signaling and its role in disease.
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DOI：
10.1016/j.tcb.2011.09.003
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发表时间：
2012-01
影响因子：
19
通讯作者：
Spiegel, Sarah
中科院分区：
文献类型：
--
作者：
Maceyka, Michael;Harikumar, Kuzhuvelil B.;Milstien, Sheldon;Spiegel, Sarah
生物活性鞘脂代谢产物1 -磷酸鞘氨醇（S1P）现在被认为是许多生理和病理生理过程的关键调节剂，包括癌症、动脉粥样硬化、糖尿病和骨质疏松症。S1P由两种鞘氨醇激酶同工酶SphK1和SphK2在细胞内产生。许多细胞分泌S1P，然后S1P可以自分泌或旁分泌的方式发挥作用。S1P的大多数已知作用是由一个包含五种特异性G蛋白偶联受体的家族介导的。最近，研究表明S1P在炎症、癌症和阿尔茨海默病中还具有重要的细胞内靶点。这表明S1P的作用比以前认为的要复杂得多，这对治疗方法的开发具有重要影响。这篇综述强调了我们在理解S1P作用机制及其在疾病中的作用方面的最新进展。
The bioactive sphingolipid metabolite, sphingosine-1-phosphate (S1P), is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis. S1P is produced in cells by two sphingosine kinase isoenzymes, SphK1 and SphK2. Many cells secrete S1P, which can then act in an autocrine or paracrine manner. Most of the known actions of S1P are mediated by a family of five specific G protein-coupled receptors. More recently, it was shown that S1P also has important intracellular targets involved in inflammation, cancer and Alzheimer’s disease. This suggests that S1P actions are much more complex than previously thought, with important ramifications for development of therapeutics. This review highlights recent advances in our understanding of mechanisms of action of S1P and its roles in disease.
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DOI：
10.1158/1078-0432.ccr-10-2323
发表时间：
2011-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dickson MA;Carvajal RD;Merrill AH Jr;Gonen M;Cane LM;Schwartz GK
通讯作者：
Schwartz GK
DOI：
10.1164/rccm.200906-0826oc
发表时间：
2010-02-15
影响因子：
24.7
作者：
Diab, Khalil J.;Adamowicz, Jeremy J.;Petrache, Irina
通讯作者：
Petrache, Irina
影响因子：
19.6
作者：
Awad AS;Rouse MD;Khutsishvili K;Huang L;Bolton WK;Lynch KR;Okusa MD
通讯作者：
Okusa MD
鞘氨醇激酶同种型的药理抑制会改变人类乳腺癌中的雌激素受体信号传导。
影响因子：
3.5
作者：
Antoon JW;Meacham WD;Bratton MR;Slaughter EM;Rhodes LV;Ashe HB;Wiese TE;Burow ME;Beckman BS
通讯作者：
Beckman BS
影响因子：
6.5
作者：
Fox, Todd E.;Bewley, Maria C.;Kester, Mark
通讯作者：
Kester, Mark