Genomic minimalism in the early diverging intestinal parasite Giardia lamblia
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia
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DOI：
10.1126/science.1143837
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发表时间：
2007-09-28
期刊：
影响因子：
56.9
通讯作者：
Sogin, Mitchell L.
中科院分区：
文献类型：
--
作者：
Morrison, Hilary G.;McArthur, Andrew G.;Sogin, Mitchell L.
真核生物蓝氏贾第鞭毛虫（Giardia lamblia）是一种重要的人类肠道寄生虫，其基因组结构和内容紧凑，包含很少的内含子或线粒体遗迹，并简化了DNA复制，转录，RNA加工和大多数代谢途径的机制。蛋白激酶包括单一最大的蛋白类，反映了贾第虫对协调分化的复杂信号转导网络的需求。来自细菌和古细菌供体的横向基因转移塑造了贾第虫的基因组，并且发现了以前未知的基因家族，例如富含半胱氨酸的结构蛋白。出乎意料的是，基因组几乎没有显示出杂合性的证据，支持了最近的推测，即这种生物是有性的。这个基因组序列不仅对研究真核生物的进化有价值，而且还将用于寻找这种寄生虫的新疗法。
The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways. Protein kinases comprise the single largest protein class and reflect Giardia's requirement for a complex signal transduction network for coordinating differentiation. Lateral gene transfer from bacterial and archaeal donors has shaped Giardia's genome, and previously unknown gene families, for example, cysteine-rich structural proteins, have been discovered. Unexpectedly, the genome shows little evidence of heterozygosity, supporting recent speculations that this organism is sexual. This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite.