KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites.

KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites.
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Kinasephos:用于识别蛋白激酶特异性磷酸化位点的Web工具。

DOI:
10.1093/nar/gki471
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发表时间:
2005-07-01
影响因子:
14.9
通讯作者:
Horng, JT
Horng, JT
中科院分区:
生物学2区
文献类型:
--
作者:
Huang, HD;Lee, TY;Tzeng, SW;Horng, JT

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KinasePhos是一种新型的网络服务器,用于计算识别催化激酶特异性磷酸化位点。来自公共领域数据源的已知磷酸化位点通过其注释的蛋白激酶进行分类。基于轮廓隐马尔可夫模型,从磷酸化位点的激酶特异性组学习计算模型。在评估学习的模型后,从每个激酶特异性组中选择具有最高准确度的模型,用于基于网络的预测工具中,以识别蛋白质磷酸化位点。因此,本工作开发了一种具有高灵敏度和特异性的激酶特异性磷酸化位点预测工具。该预测工具可在免费获得。
KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at .
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发表时间: 2004-05-01
影响因子: 4.4
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