Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo
Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo
复制标题
DOI：
10.1016/j.matbio.2015.01.012
复制
发表时间：
2015-05-01
期刊：
影响因子：
6.9
通讯作者：
Sagi, Irit
中科院分区：
文献类型：
--
作者：
Gaffney, Jean;Solomonov, Inna;Sagi, Irit
基质金属蛋白酶(MMPs)在细胞外基质(ECM)在正常稳态和病理状态下的不可逆重塑中起着至关重要的作用。从各种研究中积累的数据有力地表明，MMPs受到严格的调控，从基因表达水平一直到酶原激活和内源性抑制，每个水平都受到多个因素的控制。最近的体内研究表明，细胞外基质和细胞外基质之间的相互作用，以及细胞外基质生物活性产物，在所有水平上都提供了额外的一层调节，表明个体基质金属蛋白酶在体内的表达和活性是高度协调的和组织特异性的过程。(C)由爱思唯尔出版的2015年。
The matrix metalloproteinases (MMPs) play a crucial role in irreversible remodeling of the extracellular matrix (ECM) in normal homeostasis and pathological states. Accumulating data from various studies strongly suggest that MMPs are tightly regulated, starting from the level of gene expression all the way to zymogen activation and endogenous inhibition, with each level controlled by multiple factors. Recent in vivo findings indicate that cell ECM and cell cell interactions, as well as ECM bio-active products, contribute an additional layer of regulation at all levels, indicating that individual MMP expression and activity in vivo are highly coordinated and tissue specific processes. (C) 2015 Published by Elsevier B.V.