MHC of nonhuman primates.
MHC of nonhuman primates.
复制标题
DOI：
10.1007/978-3-642-78536-8_8
复制
发表时间：
1994
影响因子：
--
通讯作者：
D. Watkins
中科院分区：
文献类型：
--
作者：
D. Watkins
通过对非人类灵长类动物的研究，我们对艾滋病的认识得到了扩展。在猕猴中进行的几项疫苗研究表明，在适当免疫的猴中可产生对SIV的强烈免疫应答（Murphy-Corbet al. 1989; Desrosierset al. 1989）。此外，这些研究首次证明，有可能诱导针对艾滋病毒的保护性免疫反应。对SIV的细胞介导的免疫应答可能被证明是这种疫苗保护的关键。然而，要了解免疫猴和感染猴对SIV细胞反应的性质，了解与病毒识别有关的MHC产物至关重要。事实上，在远系繁殖的人群中，如果不了解所涉及的MHC产物，就不能确定对病原体的细胞免疫应答。
Our understanding of AIDS has been expanded by studies in nonhuman primates. Several vaccine studies in macaques have suggested that a strong immune response to SIV can be generated in appropriately immunized monkeys (Murphy-Corbet al. 1989; Desrosierset al. 1989). Furthermore, these studies provided the first demonstration that it may be possible to induce a protective immune response against HIV. The cell-mediated immune response to SIV may prove crucial for this vaccine protection. However, to understand the nature of the cellular response to SIV in both immunized and infected monkeys, knowledge of the MHC products involved in the recognition of the virus is crucial. Indeed, in outbred populations, definition of the cellular immune response to a pathogen cannot be carried out without the knowledge of the MHC products involved.